PMID- 22650039
OWN - NLM
STAT- MEDLINE
DCOM- 20130530
LR  - 20120601
IS  - 1672-173X (Print)
IS  - 1672-173X (Linking)
VI  - 43
IP  - 2
DP  - 2012 Mar
TI  - [Changes of BDNF expression in neurons in traumatic brain injury rats].
PG  - 236-9, 249
AB  - OBJECTIVE: To investigate changes of brain derived neurotrophic factor (BDNF) 
      expression in neurons in traumatic brain injury (TBI) rats. METHODS: Adult SD 
      rats were divided into sham and operated group resulted from hammer fall 
      contusion (30 cm high, 50 g weight). Thirteen rats in each group were used. Some 
      of animals (n = 6 in each group) were used to perform immunohistochemistry and in 
      situ hybridization, and the other (n = 7) was used for RT-PCR. After NSS 
      assessment was determined at 1, 3, 8, 13 days, TBI rats were sacrificed, brain 
      tissues were then harvested to measure BDNF level. Data were analyzed by using 
      statistic method. RESULTS: A increased NSS scores (P < 0.05) was observed after 
      TBI, which implied the significant neurobehavioral changes in rats. But a gradual 
      decreasing NSS scores (P < 0.05) was also observed along with time prolonged. 
      Severe neurological severity function was seen following TBI, and it presents a 
      gradual improvement indicated by decreasing NSS scores, despite BDNF mRNA level 
      in whole brain tissue did not present a significant change, the BDNF expression 
      (indicated by optical density values analysis) in subcellular structure, known as 
      neurons, exhibited a significant increase, when compared with that of sham group 
      (P < 0.05). This could simultaneously accompany with the decrease in the number 
      of neurons in TBI rats. CONCLUSION: TBI rats exhibit a neuroplasticity with the 
      BDNF upregulation in neurons following injury.
FAU - Zhao, Bo
AU  - Zhao B
AD  - Radiology Department, Yunnan No. 2 People's Hospital, Kunming 650000, China.
FAU - Tang, Hai-Ling
AU  - Tang HL
FAU - Dan, Qi-Qin
AU  - Dan QQ
FAU - Zhao, Nan
AU  - Zhao N
FAU - Liu, Jia
AU  - Liu J
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Sichuan Da Xue Xue Bao Yi Xue Ban
JT  - Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical 
      science edition
JID - 101162609
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Animals
MH  - Brain Injuries/*metabolism
MH  - Brain-Derived Neurotrophic Factor/genetics/*metabolism
MH  - Male
MH  - Neuronal Plasticity/physiology
MH  - Neurons/metabolism
MH  - RNA, Messenger/genetics/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
EDAT- 2012/06/02 06:00
MHDA- 2013/06/01 06:00
CRDT- 2012/06/02 06:00
PHST- 2012/06/02 06:00 [entrez]
PHST- 2012/06/02 06:00 [pubmed]
PHST- 2013/06/01 06:00 [medline]
PST - ppublish
SO  - Sichuan Da Xue Xue Bao Yi Xue Ban. 2012 Mar;43(2):236-9, 249.