PMID- 22650040
OWN - NLM
STAT- MEDLINE
DCOM- 20130530
LR  - 20120601
IS  - 1672-173X (Print)
IS  - 1672-173X (Linking)
VI  - 43
IP  - 2
DP  - 2012 Mar
TI  - [Effect of gold belt on the BDNF and NMDA receptor expression and behaviour 
      changes in rats following traumatic spinal cord injury].
PG  - 240-4
AB  - OBJECTIVE: To study the effects of gold belt (GB), a Chinese Herbal, on 
      behavioral changes and brain derived neutrophic factor (BDNF) expression and 
      N-methyl-D-aspartic acid (NMDA) receptor level in rats subjected to spinal cord 
      injury (SCI). METHODS: Adult male SD rats were randomly divided into three 
      groups: (1) Sham group; (2) Spinal cord injury group (SCI group); (3) Spinal cord 
      injury followed with gold belt treatment (gold belt 50 mg/(kg x d), intragastric 
      gavage once daily for 7 days) group (GB group). The Basso, Beattie and Bresnahan 
      (BBB) locomotor scale method was performed to evaluate the hindlimb motor 
      function in the days 0, 3, 10 and 28. After 13 days, 8 rats in each group were 
      treated with 1% sodium pentobarbital (30 mg/kg), myoloid tissue in T10 position 
      was taken and stored in liquid nitrogen to detect NMDA receptor affinity and 
      maximum binding amount (Bmax) with radioligand binding assay. After 28 days, rats 
      were sacrificed and the spinal cords were harvested for immunohistochemistry to 
      observe the localization of BDNF in the ventral and dorsal horn of the spinal 
      cord. RESULTS: After spinal cord contusion, GB resulted in a significant increase 
      on the number of BDNF positive neurons compared with traumatic group, and 
      increased BBB score and decreased NMDA receptor were also found in GB group. 
      Whereas decreased BDNF expression, NMDA receptor affininty (Kd) were observed in 
      traumatic injury group. CONCLUSION: The gold belt treatment could effectively 
      improve motor function, increase expression of BDNF, reduce the level of NMDA 
      receptors in SCI rats. These data suggested that the gold belt played a role in 
      the neuroplasticity after spinal cord injury.
FAU - Xu, Zheng-Guang
AU  - Xu ZG
AD  - LDepartment of Bone Injury, Yuxi Municipal Hospital of Traditional Chinese 
      Medicine, Yuxi 653100, China.
FAU - Yang, Jun
AU  - Yang J
FAU - Lu, Zhi-Ping
AU  - Lu ZP
FAU - Sun, Yan-Hua
AU  - Sun YH
FAU - Ru, Jin
AU  - Ru J
FAU - Li, Xiao-Song
AU  - Li XS
FAU - Liu, Jiang-Hua
AU  - Liu JH
FAU - Dan, Qi-Qin
AU  - Dan QQ
FAU - Zhao, Nan
AU  - Zhao N
FAU - Xiyang, Yan-Bin
AU  - Xiyang YB
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Sichuan Da Xue Xue Bao Yi Xue Ban
JT  - Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical 
      science edition
JID - 101162609
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/genetics/*metabolism
MH  - Drugs, Chinese Herbal/therapeutic use
MH  - Male
MH  - Motor Activity/*drug effects
MH  - Neuronal Plasticity/drug effects
MH  - Neurons/metabolism
MH  - *Phytotherapy
MH  - RNA, Messenger/genetics/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, N-Methyl-D-Aspartate/genetics/*metabolism
MH  - Spinal Cord Injuries/*drug therapy/metabolism
EDAT- 2012/06/02 06:00
MHDA- 2013/06/01 06:00
CRDT- 2012/06/02 06:00
PHST- 2012/06/02 06:00 [entrez]
PHST- 2012/06/02 06:00 [pubmed]
PHST- 2013/06/01 06:00 [medline]
PST - ppublish
SO  - Sichuan Da Xue Xue Bao Yi Xue Ban. 2012 Mar;43(2):240-4.