PMID- 22650374
OWN - NLM
STAT- MEDLINE
DCOM- 20130801
LR  - 20190907
IS  - 1873-4294 (Electronic)
IS  - 1568-0266 (Linking)
VI  - 12
IP  - 13
DP  - 2012
TI  - TNF-alpha inhibitors with anti-oxidative stress activity from natural products.
PG  - 1408-21
AB  - Tumor necrosis factor-alpha (TNF-alpha) is a major cytokine involved in the inflammatory 
      response. Elevated TNF-alpha expression has been found to be associated with the 
      development of diabetes, septic shock, tumorigenesis, cardiovascular diseases, 
      rheumatoid arthritis and inflammatory bowel disease. In the past decade, the 
      success of anti-TNF-alpha biologics has valuated the importance of the blockade of 
      TNF-alpha production in the treatment of patients with various inflammatory diseases. 
      Oxidative stress is another important element in oxidative/inflammatory responses 
      that directly linked to oxidation of proteins, DNA and lipids. The increased 
      oxidant levels could activate nuclear factor-kappaB (NFkappa-B), signal transduction 
      and gene expression of TNF-alpha, interleukin-1 (IL-1) and other pro-inflammatory 
      cytokines. Therefore, TNF-alpha inhibitors with anti-oxidative stress activity may 
      have multiple target effect that could exhibit excellent anti-inflammatory 
      activities. The review briefly highlights the pathological roles of TNF-alpha and 
      oxidative stress in inflammation, and covers those natural products as TNF-alpha 
      inhibitors capable of anti-oxidative stress activity.
FAU - Li, Jing
AU  - Li J
AD  - School of Bioscience and Bioengineering, South China University of Technology, 
      Guangzhou 510006, China. lij@scut.edu.cn
FAU - Zhang, Huibin
AU  - Zhang H
FAU - Huang, Wenlong
AU  - Huang W
FAU - Qian, Hai
AU  - Qian H
FAU - Li, Ying
AU  - Li Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United Arab Emirates
TA  - Curr Top Med Chem
JT  - Current topics in medicinal chemistry
JID - 101119673
RN  - 0 (Biological Products)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Animals
MH  - Biological Products/chemistry/*pharmacology
MH  - Humans
MH  - Inflammation/drug therapy
MH  - Molecular Structure
MH  - Oxidative Stress/*drug effects
MH  - Signal Transduction/drug effects
MH  - Tumor Necrosis Factor-alpha/*antagonists & inhibitors/genetics/metabolism
EDAT- 2012/06/02 06:00
MHDA- 2013/08/02 06:00
CRDT- 2012/06/02 06:00
PHST- 2009/11/11 00:00 [received]
PHST- 2011/10/24 00:00 [accepted]
PHST- 2012/06/02 06:00 [entrez]
PHST- 2012/06/02 06:00 [pubmed]
PHST- 2013/08/02 06:00 [medline]
AID - CTMC-EPUB-20120531-3 [pii]
AID - 10.2174/156802612801784434 [doi]
PST - ppublish
SO  - Curr Top Med Chem. 2012;12(13):1408-21. doi: 10.2174/156802612801784434.