PMID- 22650375
OWN - NLM
STAT- MEDLINE
DCOM- 20130801
LR  - 20190907
IS  - 1873-4294 (Electronic)
IS  - 1568-0266 (Linking)
VI  - 12
IP  - 13
DP  - 2012
TI  - Therapeutic potential of natural products from terrestrial plants as TNF-alpha 
      antagonist.
PG  - 1422-35
AB  - Tumor necrosis factor-alpha (TNF-alpha) is a multifunctional cytokine produced by 
      monocytes, macrophages, neutrophils, T-cells, mast cells, epithelial cells, 
      osteoblasts and dendritic cells. It can regulate numerous cellular and biological 
      processes such as immune function, cell differentiation, proliferation, apoptosis 
      and energy metabolism. It is also involved in the pathogenesis of multiple 
      chronic inflammatory or autoimmune diseases. The biological activities of TNF-alpha 
      mediated by two receptors TNFR1 and TNFR2. Its activity can be inhibited by 
      neutralizing monoclonal antibodies or soluble TNF receptors. The inhibition of 
      its biological activities using anti TNF-alpha antibodies represents an approved 
      strategy for the treatment of various diseases like cancer, autoimmune diseases, 
      inflammations etc. The involvement of TNF-alpha cytokine in the various types of 
      diseases provide the therapeutic rationale for the development of TNF-alpha 
      antagonist. A large number of natural and synthetic compounds are currently being 
      investigated for TNF-alpha inhibitory activity. Since the synthetic molecules are 
      always associated with their side effects hence it is beneficial to develop the 
      natural strategies as the alternative sources. There are many medicinal plants 
      which are traditionally used for the treatment of the diseases associated with 
      TNF-alpha inhibition. Hence, in this review article we make an approach to provide a 
      platform for the development of TNF-alpha antagonist from natural resources.
FAU - Verma, Praveen Kumar
AU  - Verma PK
AD  - Natural Plant Products Division, Council of Scientific and Industrial 
      Research-Institute of Himalayan Bioresource Technology, Palampur-176 061, (H.P.) 
      India.
FAU - Bala, Manju
AU  - Bala M
FAU - Kumar, Neeraj
AU  - Kumar N
FAU - Singh, Bikram
AU  - Singh B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United Arab Emirates
TA  - Curr Top Med Chem
JT  - Current topics in medicinal chemistry
JID - 101119673
RN  - 0 (Biological Products)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Animals
MH  - Biological Products/chemistry/*pharmacology/therapeutic use
MH  - Humans
MH  - Molecular Structure
MH  - Plants, Medicinal/*chemistry
MH  - Tumor Necrosis Factor-alpha/*antagonists & inhibitors/metabolism
EDAT- 2012/06/02 06:00
MHDA- 2013/08/02 06:00
CRDT- 2012/06/02 06:00
PHST- 2011/12/21 00:00 [received]
PHST- 2012/04/07 00:00 [accepted]
PHST- 2012/06/02 06:00 [entrez]
PHST- 2012/06/02 06:00 [pubmed]
PHST- 2013/08/02 06:00 [medline]
AID - CTMC-EPUB-20120531-4 [pii]
AID - 10.2174/156802612801784425 [doi]
PST - ppublish
SO  - Curr Top Med Chem. 2012;12(13):1422-35. doi: 10.2174/156802612801784425.