PMID- 22652301
OWN - NLM
STAT- MEDLINE
DCOM- 20130130
LR  - 20181201
IS  - 1545-7206 (Electronic)
IS  - 0033-3182 (Linking)
VI  - 53
IP  - 5
DP  - 2012 Sep-Oct
TI  - Testing a diathesis-stress model: potential genetic risk factors for development 
      of distress in context of acute leukemia diagnosis and transplant.
PG  - 456-62
LID - 10.1016/j.psym.2012.01.004 [doi]
AB  - OBJECTIVE: Brain-derived neurotrophic factor (BDNF) is a nerve growth factor that 
      has antidepressant-like effects in animals and may be implicated in the etiology 
      of mood-related phenotypes, specifically in the context of stressful life events. 
      We hypothesized that this single-nucleotide polymorphism will predict the 
      development of psychological distress among patients diagnosed with acute 
      leukemia and preparing for hematopoietic stem cell transplant (HSCT). We also 
      explored the relationship of other genetic factors to psychological distress, 
      including 5HTTLPR and STin2, FKBP5, and the CRHR1 TAT haplotype. METHOD: In a 
      retrospective cohort design, 107 adult acute leukemia survivors preparing for 
      HSCT at a major medical center completed a pre-HSCT psychological evaluation and 
      volunteered to donate blood to the HSCT Cell and Serum Research Repository for 
      future research studies. RESULTS: There was evidence of a potential association 
      between BDNF (Val66Met) and psychological distress. More specifically, rs6265 was 
      related to both personal mental health history (P = 0.09, 0.06 adjusted) and 
      diagnosis of depression/adjustment disorder at time of pre-transplant evaluation 
      (P = 0.11, 0.09 adjusted). Other genetic factors were unrelated to distress. 
      CONCLUSION: The BDNF Val66Met polymorphism may contribute to development of 
      depressive symptomatology in patients undergoing stressful life events, such as 
      diagnosis of acute leukemia and preparation for HSCT. The SNPs in BDNF might be 
      applicable in identifying patients at risk for developing psychological distress 
      and depression in the context of coping with stressful medical conditions. 
      Polymorphism in other genes (FKBP5, CRHR1, and 5HTT) did not show any significant 
      relationships. Replication studies are needed with larger samples of people 
      undergoing similar significant life stressors.
CI  - Copyright (c) 2012 The Academy of Psychosomatic Medicine. Published by Elsevier 
      Inc. All rights reserved.
FAU - Romanowicz, Magdalena
AU  - Romanowicz M
AD  - Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, 
      CA 94305, USA. mromanow@stanford.edu
FAU - Ehlers, Shawna
AU  - Ehlers S
FAU - Walker, Denise
AU  - Walker D
FAU - Decker, Paul
AU  - Decker P
FAU - Rundell, James
AU  - Rundell J
FAU - Shinozaki, Gen
AU  - Shinozaki G
FAU - Litzow, Mark
AU  - Litzow M
FAU - Hogan, William
AU  - Hogan W
FAU - Mrazek, David
AU  - Mrazek D
FAU - Black, John L
AU  - Black JL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120530
PL  - England
TA  - Psychosomatics
JT  - Psychosomatics
JID - 0376506
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Receptors, Corticotropin-Releasing Hormone)
RN  - 0 (SLC6A4 protein, human)
RN  - 0 (Serotonin Plasma Membrane Transport Proteins)
RN  - 5CLY6W2H1M (CRF receptor type 1)
RN  - EC 5.2.1.- (Tacrolimus Binding Proteins)
RN  - EC 5.2.1.8 (tacrolimus binding protein 5)
SB  - IM
MH  - Adjustment Disorders/genetics
MH  - Adult
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Cohort Studies
MH  - Depression/*genetics
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Hematopoietic Stem Cell Transplantation/*psychology
MH  - Humans
MH  - Leukemia/*psychology
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide
MH  - Receptors, Corticotropin-Releasing Hormone/genetics
MH  - Retrospective Studies
MH  - Serotonin Plasma Membrane Transport Proteins/genetics
MH  - Stress, Psychological/*genetics
MH  - Tacrolimus Binding Proteins/genetics
EDAT- 2012/06/02 06:00
MHDA- 2013/01/31 06:00
CRDT- 2012/06/02 06:00
PHST- 2011/11/13 00:00 [received]
PHST- 2012/01/05 00:00 [revised]
PHST- 2012/01/05 00:00 [accepted]
PHST- 2012/06/02 06:00 [entrez]
PHST- 2012/06/02 06:00 [pubmed]
PHST- 2013/01/31 06:00 [medline]
AID - S0033-3182(12)00005-9 [pii]
AID - 10.1016/j.psym.2012.01.004 [doi]
PST - ppublish
SO  - Psychosomatics. 2012 Sep-Oct;53(5):456-62. doi: 10.1016/j.psym.2012.01.004. Epub 
      2012 May 30.