PMID- 22652893
OWN - NLM
STAT- MEDLINE
DCOM- 20130429
LR  - 20220224
IS  - 1945-0524 (Electronic)
IS  - 1945-0516 (Linking)
VI  - 4
IP  - 4
DP  - 2012 Jun 1
TI  - Role of NK cells and HLA-G in endometriosis.
PG  - 1568-81
AB  - Impaired natural killer (NK) activity in women with endometriosis is thought to 
      promote implantation and progression of endometrial tissue, in accord with 
      Sampson's hypothesis. However, the mechanisms responsible for decreased NK cell 
      activity and the antigens recognized by NK cells are not clear.We focused on 
      human leukocyte antigen (HLA)-G, a ligand of NK receptors, expression and its 
      menstrual cycle changes by eutopic endometrium. Interestingly, HLA-G expression 
      was identified on eutopic endometrium only in the menstrual phase but not in the 
      proliferative or secretory phases. Furthermore, HLA-G expressing cells were also 
      detected in peritoneal fluid during the menstrual period. During retrograde 
      menstruation, HLA-G expressing endometrial tissue may enter the peritoneal 
      cavity, and may be reduced by immunosurveillance system. Although peritoneal NK 
      cells play an important role in this system, impairment of NK cytotoxicity via 
      HLA-G may allow peritoneal endometrial cell survival and implantation. In this 
      review, we discuss the pathogenesis of endometriosis from the viewpoint of 
      intraperitoneal immune interaction between NK cell receptors and HLA-G that can 
      enter into peritoneal cavity from eutopic endometrium through retrograde 
      menstruation.
FAU - Maeda, Nagamasa
AU  - Maeda N
AD  - Department of Obstetrics and Gynecology, Kochi Medical School, Nankoku, Kochi, 
      Japan. maedan@kochi-u.ac.jp
FAU - Izumiya, Chiaki
AU  - Izumiya C
FAU - Taniguchi, Kayo
AU  - Taniguchi K
FAU - Matsushima, Sachio
AU  - Matsushima S
FAU - Fukaya, Takao
AU  - Fukaya T
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20120601
PL  - Singapore
TA  - Front Biosci (Schol Ed)
JT  - Frontiers in bioscience (Scholar edition)
JID - 101485241
RN  - 0 (HLA-G Antigens)
SB  - IM
MH  - Endometriosis/*immunology/metabolism/pathology
MH  - Endometrium/immunology/metabolism/pathology
MH  - Female
MH  - HLA-G Antigens/*immunology
MH  - Humans
MH  - Killer Cells, Natural/*immunology/metabolism/pathology
EDAT- 2012/06/02 06:00
MHDA- 2013/04/30 06:00
CRDT- 2012/06/02 06:00
PHST- 2012/06/02 06:00 [entrez]
PHST- 2012/06/02 06:00 [pubmed]
PHST- 2013/04/30 06:00 [medline]
AID - 353 [pii]
AID - 10.2741/s353 [doi]
PST - epublish
SO  - Front Biosci (Schol Ed). 2012 Jun 1;4(4):1568-81. doi: 10.2741/s353.