PMID- 22653298
OWN - NLM
STAT- MEDLINE
DCOM- 20130926
LR  - 20211021
IS  - 1554-8635 (Electronic)
IS  - 1554-8627 (Print)
IS  - 1554-8627 (Linking)
VI  - 8
IP  - 7
DP  - 2012 Jul 1
TI  - Dietary lipids and aging compromise chaperone-mediated autophagy by similar 
      mechanisms.
PG  - 1152-4
LID - 10.4161/auto.20649 [doi]
AB  - Chaperone-mediated autophagy (CMA) is a selective form of autophagy whose 
      distinctive feature is the fact that substrate proteins are translocated directly 
      from the cytosol across the lysosomal membrane for degradation inside lysosomes. 
      CMA substrates are cytosolic proteins bearing a pentapeptide motif in their 
      sequence that, when recognized by the cytosolic chaperone HSPA8/HSC70, targets 
      them to the surface of the lysosomes. Once there, substrate proteins bind to the 
      lysosome-associated membrane protein type 2 isoform A (LAMP2A), inducing assembly 
      of this receptor protein into a higher molecular weight protein complex that is 
      used by the substrate proteins to reach the lysosomal lumen. CMA is 
      constitutively active in most cells but it is maximally activated under 
      conditions of stress.
FAU - Rodriguez-Navarro, Jose Antonio
AU  - Rodriguez-Navarro JA
AD  - Department of Developmental and Molecular Biology, Institute for Aging Studies, 
      Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, 
      NY, USA.
FAU - Cuervo, Ana Maria
AU  - Cuervo AM
LA  - eng
PT  - Comment
PT  - Journal Article
DEP - 20120606
PL  - United States
TA  - Autophagy
JT  - Autophagy
JID - 101265188
RN  - 0 (Lipids)
RN  - 0 (Lysosomal-Associated Membrane Protein 2)
RN  - 0 (Molecular Chaperones)
SB  - IM
CON - Proc Natl Acad Sci U S A. 2012 Mar 20;109(12):E705-14. PMID: 22331875
MH  - Animals
MH  - Lipids/*chemistry
MH  - Lysosomal-Associated Membrane Protein 2/*chemistry
MH  - Male
MH  - Molecular Chaperones/*chemistry
PMC - PMC3429556
OTO - NOTNLM
OT  - cholesterol
OT  - diet
OT  - lipid microdomains
OT  - lipidomic analysis
OT  - lysosomes
OT  - membrane proteins
OT  - proteolysis
EDAT- 2012/06/02 06:00
MHDA- 2013/09/27 06:00
PMCR- 2013/07/01
CRDT- 2012/06/02 06:00
PHST- 2012/06/02 06:00 [entrez]
PHST- 2012/06/02 06:00 [pubmed]
PHST- 2013/09/27 06:00 [medline]
PHST- 2013/07/01 00:00 [pmc-release]
AID - 20649 [pii]
AID - 2012AUTO0171R [pii]
AID - 10.4161/auto.20649 [doi]
PST - ppublish
SO  - Autophagy. 2012 Jul 1;8(7):1152-4. doi: 10.4161/auto.20649. Epub 2012 Jun 6.