PMID- 22654878
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120823
LR  - 20211021
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 3
DP  - 2012
TI  - Mast cell chemotaxis - chemoattractants and signaling pathways.
PG  - 119
LID - 10.3389/fimmu.2012.00119 [doi]
LID - 119
AB  - Migration of mast cells is essential for their recruitment within target tissues 
      where they play an important role in innate and adaptive immune responses. These 
      processes rely on the ability of mast cells to recognize appropriate chemotactic 
      stimuli and react to them by a chemotactic response. Another level of 
      intercellular communication is attained by production of chemoattractants by 
      activated mast cells, which results in accumulation of mast cells and other 
      hematopoietic cells at the sites of inflammation. Mast cells express numerous 
      surface receptors for various ligands with properties of potent chemoattractants. 
      They include the stem cell factor (SCF) recognized by c-Kit, antigen, which binds 
      to immunoglobulin E (IgE) anchored to the high affinity IgE receptor (FcepsilonRI), 
      highly cytokinergic (HC) IgE recognized by FcepsilonRI, lipid mediator 
      sphingosine-1-phosphate (S1P), which binds to G protein-coupled receptors 
      (GPCRs). Other large groups of chemoattractants are eicosanoids [prostaglandin 
      E(2) and D(2), leukotriene (LT) B(4), LTD(4), and LTC(4), and others] and 
      chemokines (CC, CXC, C, and CX3C), which also bind to various GPCRs. Further 
      noteworthy chemoattractants are isoforms of transforming growth factor (TGF) 
      beta1-3, which are sensitively recognized by TGF-beta serine/threonine type I and II beta 
      receptors, adenosine, C1q, C3a, and C5a components of the complement, 
      5-hydroxytryptamine, neuroendocrine peptide catestatin, tumor necrosis factor-alpha, 
      and others. Here we discuss the major types of chemoattractants recognized by 
      mast cells, their target receptors, as well as signaling pathways they utilize. 
      We also briefly deal with methods used for studies of mast cell chemotaxis and 
      with ways of how these studies profited from the results obtained in other 
      cellular systems.
FAU - Halova, Ivana
AU  - Halova I
AD  - Department of Signal Transduction, Institute of Molecular Genetics, Academy of 
      Sciences of the Czech Republic Prague, Czech Republic.
FAU - Draberova, Lubica
AU  - Draberova L
FAU - Draber, Petr
AU  - Draber P
LA  - eng
PT  - Journal Article
DEP - 20120525
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
PMC - PMC3360162
OTO - NOTNLM
OT  - IgE receptor
OT  - cell migration
OT  - chemoattractant
OT  - chemotaxis
OT  - mast cell
OT  - plasma membrane
OT  - signal transduction
EDAT- 2012/06/02 06:00
MHDA- 2012/06/02 06:01
PMCR- 2012/01/01
CRDT- 2012/06/02 06:00
PHST- 2012/02/22 00:00 [received]
PHST- 2012/04/24 00:00 [accepted]
PHST- 2012/06/02 06:00 [entrez]
PHST- 2012/06/02 06:00 [pubmed]
PHST- 2012/06/02 06:01 [medline]
PHST- 2012/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2012.00119 [doi]
PST - epublish
SO  - Front Immunol. 2012 May 25;3:119. doi: 10.3389/fimmu.2012.00119. eCollection 
      2012.