PMID- 22654885
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120823
LR  - 20211021
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 3
DP  - 2012
TI  - Tolerogenic effect of non-inherited maternal antigens in hematopoietic stem cell 
      transplantation.
PG  - 135
LID - 10.3389/fimmu.2012.00135 [doi]
LID - 135
AB  - Major histocompatibility complex antigens that provoke severe transplant 
      reactions are referred to as the human leukocyte antigen (HLA) in human and as 
      the H-2 in mice. Even if the donor and recipient are HLA-identical siblings, 
      graft-versus-host reactions have been linked to differences in the minor 
      histocompatibility antigen. As the chance of finding an HLA-identical sibling 
      donor is only 25%, attention has been focused on using alternative donors. An 
      HLA-mismatched donor with non-inherited maternal antigens (NIMA) is less 
      immunogenic than that with non-inherited paternal antigens, because the contact 
      between the immune systems of the mother and child during pregnancy affects the 
      immune response of the child against NIMA. However, the immunologic effects of 
      developmental exposure to NIMA are heterogeneous, and can be either tolerogenic 
      or immunogenic. We recently have devised a novel method for predicting the 
      tolerogenic effect of NIMA. In this review, we overview the evidence for the 
      existence of the NIMA tolerogenic effect, the possible cellular and molecular 
      basis of the phenomenon, and its utilization in hematopoietic stem cell 
      transplantation. We suggest a future direction for the safe clinical use of this 
      phenomenon, fetomaternal tolerance, in the transplantation field.
FAU - Hirayama, Masahiro
AU  - Hirayama M
AD  - Department of Pediatrics and Cell Transplantation, Mie University Graduate School 
      of Medicine, Tsu, Mie, Japan.
FAU - Azuma, Eiichi
AU  - Azuma E
FAU - Komada, Yoshihiro
AU  - Komada Y
LA  - eng
PT  - Journal Article
DEP - 20120525
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
PMC - PMC3360462
OTO - NOTNLM
OT  - NIMA
OT  - acute GVHD
OT  - hematopoietic stem cell transplantation
OT  - tolerance
EDAT- 2012/06/02 06:00
MHDA- 2012/06/02 06:01
PMCR- 2012/01/01
CRDT- 2012/06/02 06:00
PHST- 2012/03/15 00:00 [received]
PHST- 2012/05/10 00:00 [accepted]
PHST- 2012/06/02 06:00 [entrez]
PHST- 2012/06/02 06:00 [pubmed]
PHST- 2012/06/02 06:01 [medline]
PHST- 2012/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2012.00135 [doi]
PST - epublish
SO  - Front Immunol. 2012 May 25;3:135. doi: 10.3389/fimmu.2012.00135. eCollection 
      2012.