PMID- 22655217
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120823
LR  - 20220318
IS  - 2042-0072 (Electronic)
IS  - 2090-8067 (Print)
VI  - 2012
DP  - 2012
TI  - Changes of TSH-Stimulation Blocking Antibody (TSBAb) and Thyroid Stimulating 
      Antibody (TSAb) Over 10 Years in 34 TSBAb-Positive Patients with Hypothyroidism 
      and in 98 TSAb-Positive Graves' Patients with Hyperthyroidism: Reevaluation of 
      TSBAb and TSAb in TSH-Receptor-Antibody (TRAb)-Positive Patients.
PG  - 182176
LID - 10.1155/2012/182176 [doi]
LID - 182176
AB  - TWO TRABS: TSBAb and TSAb. TSBAb causes hypothyroidism. TSAb causes Graves' 
      hyperthyroidism. TSBAb and TSAb block TSH-binding to cells as TRAb, measured as 
      TSH-binding inhibitory immunoglobulin (TBII). We reevaluate TSBAb and TSAb. We 
      studied TSBAb, TSAb, and TBII over 10 years in 34 TSBAb-positives with 
      hypothyroidism and in 98 TSAb-positives with hyperthyroidism. Half of the 34 
      TSBAb-positives with hypothyroidism continued to have persistently positive 
      TSBAb, continued to have hypothyroidism, and did not recover from hypothyroidism. 
      Ten of the 98 TSAb-positives with hyperthyroidism continued to have positive TSAb 
      and continued to have hyperthyroidism. TSBAb had disappeared in 15 of the 34 
      TSBAb-positives with hypothyroidism. With the disappearance of TSBAb, recovery 
      from hypothyroidism was noted in 13 (87%) of the 15 patients. TSAb had 
      disappeared in 73 of the 98 TSAb-positives with hyperthyroidism. With the 
      disappearance of TSAb, remissions of hyperthyroidism were noted in 60 (82%) of 
      the 73. Two of the 34 TSBAb-positives with hypothyroidism developed TSAb-positive 
      Graves' hyperthyroidism. Two of the 98 TSAb-positive Graves' patients with 
      hyperthyroidism developed TSBAb-positive hypothyroidism. TSBAb and TSAb are 
      TRAbs. TSBAb-hypothyroidism and TSAb-hyperthyroidism may be two aspects of one 
      disease (TRAb disease). Two forms of autoimmune thyroiditis: atrophic and 
      goitrous. We followed 34 TSBAb-positive patients with hypothyroidism (24 atrophic 
      and 10 goitrous) over 10 years. All of the 10 TSBAb-positive goitrous patients 
      recovered from hypothyroidism and 19 (79%) of the 24 TSBAb-positive atrophic 
      patients continued to have hypothyroidism.
FAU - Takasu, Nobuyuki
AU  - Takasu N
AD  - Department of Endocrinology and Metabolism, Aizawa Hospital, 2-5-1 Honjo, 
      Mtasumoto 390-8521, Japan.
FAU - Matsushita, Mina
AU  - Matsushita M
LA  - eng
PT  - Journal Article
DEP - 20120510
PL  - United States
TA  - J Thyroid Res
JT  - Journal of thyroid research
JID - 101536655
PMC - PMC3359712
EDAT- 2012/06/02 06:00
MHDA- 2012/06/02 06:01
PMCR- 2012/05/10
CRDT- 2012/06/02 06:00
PHST- 2011/08/31 00:00 [received]
PHST- 2012/01/22 00:00 [revised]
PHST- 2012/01/24 00:00 [accepted]
PHST- 2012/06/02 06:00 [entrez]
PHST- 2012/06/02 06:00 [pubmed]
PHST- 2012/06/02 06:01 [medline]
PHST- 2012/05/10 00:00 [pmc-release]
AID - 10.1155/2012/182176 [doi]
PST - ppublish
SO  - J Thyroid Res. 2012;2012:182176. doi: 10.1155/2012/182176. Epub 2012 May 10.