PMID- 22655432
OWN - NLM
STAT- MEDLINE
DCOM- 20120703
LR  - 20181201
IS  - 0043-3284 (Print)
IS  - 0043-3284 (Linking)
VI  - 108
IP  - 2
DP  - 2012 Mar-Apr
TI  - Acromegaly caused by growth hormone releasing hormone (GHRH) secreting tumor in 
      multiple endocrine neoplasia (MEN-1).
PG  - 26-30
AB  - We are presenting the clinical features, diagnostic work up and treatment of 
      acromegaly caused by Growth hormone releasing hormone (GHRH) secreting 
      neuroendocrine tumor (NECT) in a case of multiple endocrine neoplasia type 1 
      (MEN-1). A 36 year old man, known case of MEN-1 presented with acromegalic 
      features. He has high IGF-1, GH and very high GHRH levels with a pancreatic head 
      tumor and pituitary mass. He had high GHRH arteriovenous gradient across 
      pancreatic tumor and underwent tumor resection, Post operative GHRH level fell 
      dramatically. Tumor had high GHRH m-RNA level. Acromegalic patients with MEN-1 
      should be screened for ectopic GHRH secretion. Measurement of GHRH arteriovenous 
      gradient across NECT or mRNA for GHRH in resected tumor can confirm the ectopic 
      source. Treatment of choice is surgical resection of the tumor. Somatostatin 
      analogue is an alternative because of its dual action in the pituitary gland and 
      the NECT. Life long surveillance is needed as recurrence chance is high.
FAU - Saleem, Tipu Faiz M
AU  - Saleem TF
AD  - Division of Endocrinology, JCESOM, Marshall University Huntington, USA.
FAU - Santhanam, Prasanna
AU  - Santhanam P
FAU - Hamoudeh, Eyad
AU  - Hamoudeh E
FAU - Hassan, Tamer
AU  - Hassan T
FAU - Faiz, Saba
AU  - Faiz S
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - W V Med J
JT  - The West Virginia medical journal
JID - 0413777
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
RN  - 9034-39-3 (Growth Hormone-Releasing Hormone)
SB  - IM
MH  - Acromegaly/*diagnosis/etiology/metabolism
MH  - Adult
MH  - Growth Hormone-Releasing Hormone/*metabolism
MH  - Humans
MH  - Insulin-Like Growth Factor I
MH  - Male
MH  - Multiple Endocrine Neoplasia/complications/*diagnosis/metabolism/surgery
MH  - Neuroendocrine Tumors/complications/*diagnosis/metabolism/surgery
MH  - Pancreatic Neoplasms/complications/*diagnosis/metabolism/surgery
EDAT- 2012/06/05 06:00
MHDA- 2012/07/04 06:00
CRDT- 2012/06/05 06:00
PHST- 2012/06/05 06:00 [entrez]
PHST- 2012/06/05 06:00 [pubmed]
PHST- 2012/07/04 06:00 [medline]
PST - ppublish
SO  - W V Med J. 2012 Mar-Apr;108(2):26-30.