PMID- 22657104
OWN - NLM
STAT- MEDLINE
DCOM- 20140713
LR  - 20181202
IS  - 1476-8259 (Electronic)
IS  - 1025-5842 (Linking)
VI  - 17
IP  - 5
DP  - 2014 Apr
TI  - An innovative numerical approach to resolve the pulse wave velocity in a healthy 
      thoracic aorta model.
PG  - 461-73
LID - 10.1080/10255842.2012.691476 [doi]
AB  - Aortic dissection and atherosclerosis are highly fatal diseases. The development 
      of both diseases is closely associated with highly complex haemodynamics. Thus, 
      in predicting the onset of cardiac disease, it is desirable to obtain a detailed 
      understanding of the flowfield characteristics in the human cardiovascular 
      circulatory system. Accordingly, in this study, a numerical model of a normal 
      human thoracic aorta is constructed using the geometry information obtained from 
      a phase-contrast magnetic resonance imaging (PC-MRI) technique. The interaction 
      between the blood flow and the vessel wall dynamics is then investigated using a 
      coupled fluid-structure interaction (FSI) analysis. The simulations focus 
      specifically on the flowfield characteristics and pulse wave velocity (PWV) of 
      the blood flow. Instead of using a conventional PC-MRI method to measure PWV, we 
      present an innovative application of using the FSI approach to numerically 
      resolve PWV for the assessment of wall compliance in a thoracic aorta model. The 
      estimated PWV for a normal thoracic aorta agrees well with the results obtained 
      via PC-MRI measurement. In addition, simulations which consider the FSI effect 
      yield a lower predicted value of the wall shear stress at certain locations in 
      the cardiac cycle than models which assume a rigid vessel wall. Consequently, the 
      model provides a suitable basis for the future development of more sophisticated 
      methods capable of performing the computer-aided analysis of aortic blood flows.
FAU - Yang, An-Shik
AU  - Yang AS
AD  - a Department of Energy and Refrigerating Air-Conditioning Engineering , National 
      Taipei University of Technology , 1, Section 3, Chung-Hsiao E. Road, Taipei 106 , 
      Taiwan R.O.C.
FAU - Wen, Chih-Yung
AU  - Wen CY
FAU - Tseng, Li-Yu
AU  - Tseng LY
FAU - Chiang, Chih-Chieh
AU  - Chiang CC
FAU - Tseng, Wen-Yih Isaac
AU  - Tseng WY
FAU - Yu, Hsi-Yu
AU  - Yu HY
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120601
PL  - England
TA  - Comput Methods Biomech Biomed Engin
JT  - Computer methods in biomechanics and biomedical engineering
JID - 9802899
SB  - IM
MH  - Adult
MH  - Aorta, Thoracic/anatomy & histology/*physiology
MH  - Compliance
MH  - Hemodynamics
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Models, Anatomic
MH  - Pulse Wave Analysis/*methods
EDAT- 2012/06/05 06:00
MHDA- 2014/07/14 06:00
CRDT- 2012/06/05 06:00
PHST- 2012/06/05 06:00 [entrez]
PHST- 2012/06/05 06:00 [pubmed]
PHST- 2014/07/14 06:00 [medline]
AID - 10.1080/10255842.2012.691476 [doi]
PST - ppublish
SO  - Comput Methods Biomech Biomed Engin. 2014 Apr;17(5):461-73. doi: 
      10.1080/10255842.2012.691476. Epub 2012 Jun 1.