PMID- 22658696
OWN - NLM
STAT- MEDLINE
DCOM- 20130418
LR  - 20151119
IS  - 1876-4738 (Electronic)
IS  - 0914-5087 (Linking)
VI  - 60
IP  - 3
DP  - 2012 Sep
TI  - Comparison of inflammatory markers between diabetic and nondiabetic ST segment 
      elevation myocardial infarction.
PG  - 204-9
LID - S0914-5087(12)00088-3 [pii]
LID - 10.1016/j.jjcc.2012.03.006 [doi]
AB  - BACKGROUND: Inflammation plays a significant role in acute coronary syndrome 
      (ACS) and type 2 diabetes mellitus (DM). There may be similar inflammatory 
      changes in non-DM patients with ST elevation myocardial infarction (STEMI) and DM 
      patients with stable angina (SA), and DM patients with STEMI may have more severe 
      changes than the former two groups. The objectives of this study were to 
      investigate whether the level of inflammation was similar in patients with non-DM 
      STEMI and DM SA, and to evaluate whether the changes in the level of inflammation 
      were more severe in patients with DM STEMI compared to the other two groups. 
      METHODS AND RESULTS: A variety of inflammatory markers including: highly 
      sensitive C-reactive protein (hsCRP), erythrocyte sedimentation rate (ESR), 
      interleukin-6 (IL-6), IL-18, vascular cell adhesion molecule-1 (VCAM-1), and 
      matrix metallopeptidase-9 (MMP-9) as well as insulin resistance were compared 
      among the three groups: DM STEMI (90 patients), DM SA (91 patients), and non-DM 
      STEMI (76 patients). Inflammatory marker levels were not significantly different 
      between the DM SA and non-DM STEMI groups. However, hsCRP and IL-6 were increased 
      in the DM STEMI compared to the DM SA patients (p=0.005 and p=0.004, 
      respectively). In addition, hsCRP, ESR, and IL-18 were increased in the DM STEMI 
      compared to the non-DM STEMI patients (p=0.017, p=0.020, and p=0.033, 
      respectively). Furthermore, the fasting insulin and the homeostasis model 
      assessment were significantly increased in the DM STEMI compared to the DM SA 
      patients (p=0.04 and p=0.004, respectively). CONCLUSIONS: DM SA and non-DM STEMI 
      may have similar inflammatory changes. DM STEMI may be a more severe inflammatory 
      condition compared to patients with DM SA or non-DM STEMI.
CI  - Copyright (c) 2012 Japanese College of Cardiology. Published by Elsevier Ltd. All 
      rights reserved.
FAU - Heo, Ji Man
AU  - Heo JM
AD  - Department of Cardiology, Cardiovascular Center, Korea University Anam Hospital, 
      Seoul, Republic of Korea.
FAU - Park, Jae Hyoung
AU  - Park JH
FAU - Kim, Ju Hyeon
AU  - Kim JH
FAU - You, Sung Hae
AU  - You SH
FAU - Kim, Je Sang
AU  - Kim JS
FAU - Ahn, Chul-Min
AU  - Ahn CM
FAU - Hong, Soon Jun
AU  - Hong SJ
FAU - Shin, Kyung-Ho
AU  - Shin KH
FAU - Lim, Do-Sun
AU  - Lim DS
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120531
PL  - Netherlands
TA  - J Cardiol
JT  - Journal of cardiology
JID - 8804703
RN  - 0 (Biomarkers)
RN  - 0 (Interleukin-18)
RN  - 0 (Interleukin-6)
RN  - 0 (Vascular Cell Adhesion Molecule-1)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - EC 3.4.24.35 (Matrix Metalloproteinase 9)
SB  - IM
MH  - Angina, Stable/complications
MH  - Biomarkers/blood
MH  - Blood Sedimentation
MH  - C-Reactive Protein/analysis
MH  - Diabetes Mellitus, Type 2/*complications
MH  - Electrocardiography
MH  - Female
MH  - Humans
MH  - Inflammation/*blood
MH  - Insulin Resistance
MH  - Interleukin-18/blood
MH  - Interleukin-6/blood
MH  - Male
MH  - Matrix Metalloproteinase 9/blood
MH  - Middle Aged
MH  - Myocardial Infarction/*blood/complications/*physiopathology
MH  - Vascular Cell Adhesion Molecule-1/blood
EDAT- 2012/06/05 06:00
MHDA- 2013/04/20 06:00
CRDT- 2012/06/05 06:00
PHST- 2011/12/22 00:00 [received]
PHST- 2012/03/10 00:00 [revised]
PHST- 2012/03/13 00:00 [accepted]
PHST- 2012/06/05 06:00 [entrez]
PHST- 2012/06/05 06:00 [pubmed]
PHST- 2013/04/20 06:00 [medline]
AID - S0914-5087(12)00088-3 [pii]
AID - 10.1016/j.jjcc.2012.03.006 [doi]
PST - ppublish
SO  - J Cardiol. 2012 Sep;60(3):204-9. doi: 10.1016/j.jjcc.2012.03.006. Epub 2012 May 
      31.