PMID- 22659718
OWN - NLM
STAT- MEDLINE
DCOM- 20121001
LR  - 20120604
IS  - 1537-1603 (Electronic)
IS  - 0736-0258 (Linking)
VI  - 29
IP  - 3
DP  - 2012 Jun
TI  - Cortical excitability in migraine and epilepsy: a common feature?
PG  - 244-9
LID - 10.1097/WNP.0b013e3182570fee [doi]
AB  - OBJECTIVE: There is evidence for comorbidity of migraine and epilepsy. We used 
      transcranial magnetic stimulation (TMS) to assess cortical excitability in 
      migraine compared with control subjects and patients with epilepsy. METHODS: 
      Twenty-six patients drug-naive patients with newly diagnosed migraine were 
      studied. These were compared with 19 healthy control subjects and 50 patients 
      with new onset epilepsy. Motor threshold (MT) and responses to paired pulse 
      stimulation at short (2, 5, 10, and 15 milliseconds) and long (50-400 
      milliseconds) interstimulus intervals (ISIs) were measured. RESULTS: Compared 
      with control subjects, cortical excitability was higher in migraine only at 250 
      milliseconds (P < 0.05; effect size 0.7), while in epilepsy, it was higher at 2, 
      5, 250, and 300 milliseconds. Compared with epilepsy, cortical excitability was 
      lower in migraine only at 250 milliseconds (P < 0.05; effect size 0.6 compared 
      with focal epilepsy and 1.1 compared with idiopathic generalized epilepsy [IGE]). 
      CONCLUSIONS: Cortical excitability increases in migraine suggesting the 
      involvement of intracortical inhibitory circuits. This may be a common feature 
      underlying some of the similarities observed in migraine and epilepsy.
FAU - Badawy, Radwa A B
AU  - Badawy RA
AD  - Department of Neurology, Austin Health, Heidelberg, Australia. 
      badawyr@unimelb.edu.au
FAU - Jackson, Graeme D
AU  - Jackson GD
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Clin Neurophysiol
JT  - Journal of clinical neurophysiology : official publication of the American 
      Electroencephalographic Society
JID - 8506708
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Cerebral Cortex/*physiopathology
MH  - Epilepsy/*physiopathology
MH  - Evoked Potentials, Motor/physiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Migraine Disorders/*physiopathology
MH  - Transcranial Magnetic Stimulation
MH  - Young Adult
EDAT- 2012/06/05 06:00
MHDA- 2012/10/02 06:00
CRDT- 2012/06/05 06:00
PHST- 2012/06/05 06:00 [entrez]
PHST- 2012/06/05 06:00 [pubmed]
PHST- 2012/10/02 06:00 [medline]
AID - 00004691-201206000-00007 [pii]
AID - 10.1097/WNP.0b013e3182570fee [doi]
PST - ppublish
SO  - J Clin Neurophysiol. 2012 Jun;29(3):244-9. doi: 10.1097/WNP.0b013e3182570fee.