PMID- 22661087
OWN - NLM
STAT- MEDLINE
DCOM- 20120907
LR  - 20181201
IS  - 1550-6606 (Electronic)
IS  - 0022-1767 (Linking)
VI  - 189
IP  - 1
DP  - 2012 Jul 1
TI  - Zinc supplementation during pregnancy protects against lipopolysaccharide-induced 
      fetal growth restriction and demise through its anti-inflammatory effect.
PG  - 454-63
LID - 10.4049/jimmunol.1103579 [doi]
AB  - LPS is associated with adverse developmental outcomes, including preterm 
      delivery, fetal death, teratogenicity, and intrauterine growth restriction 
      (IUGR). Previous reports showed that zinc protected against LPS-induced 
      teratogenicity. In the current study, we investigated the effects of zinc 
      supplementation during pregnancy on LPS-induced preterm delivery, fetal death and 
      IUGR. All pregnant mice except controls were i.p. injected with LPS (75 mug/kg) 
      daily from gestational day (GD) 15 to GD17. Some pregnant mice were administered 
      zinc sulfate through drinking water (75 mg elemental Zn per liter) throughout the 
      pregnancy. As expected, an i.p. injection with LPS daily from GD15 to GD17 
      resulted in 36.4% (4/11) of dams delivered before GD18. In dams that completed 
      the pregnancy, 63.2% of fetuses were dead. Moreover, LPS significantly reduced 
      fetal weight and crown-rump length. Of interest, zinc supplementation during 
      pregnancy protected mice from LPS-induced preterm delivery and fetal death. In 
      addition, zinc supplementation significantly alleviated LPS-induced IUGR and 
      skeletal development retardation. Further experiments showed that zinc 
      supplementation significantly attenuated LPS-induced expression of placental 
      inflammatory cytokines and cyclooxygenase-2. Zinc supplementation also 
      significantly attenuated LPS-induced activation of NF-kappaB and MAPK signaling in 
      mononuclear sinusoidal trophoblast giant cells of the labyrinth zone. It 
      inhibited LPS-induced placental AKT phosphorylation as well. In conclusion, zinc 
      supplementation during pregnancy protects against LPS-induced fetal growth 
      restriction and demise through its anti-inflammatory effect.
FAU - Chen, Yuan-Hua
AU  - Chen YH
AD  - Department of Toxicology, Anhui Medical University, Hefei 230032, China.
FAU - Zhao, Mei
AU  - Zhao M
FAU - Chen, Xue
AU  - Chen X
FAU - Zhang, Ying
AU  - Zhang Y
FAU - Wang, Hua
AU  - Wang H
FAU - Huang, Ying-Ying
AU  - Huang YY
FAU - Wang, Zhen
AU  - Wang Z
FAU - Zhang, Zhi-Hui
AU  - Zhang ZH
FAU - Zhang, Cheng
AU  - Zhang C
FAU - Xu, De-Xiang
AU  - Xu DX
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120601
PL  - United States
TA  - J Immunol
JT  - Journal of immunology (Baltimore, Md. : 1950)
JID - 2985117R
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 0 (Lipopolysaccharides)
RN  - J41CSQ7QDS (Zinc)
SB  - IM
MH  - Animals
MH  - Anti-Inflammatory Agents, Non-Steroidal/*administration & dosage/therapeutic use
MH  - *Dietary Supplements/statistics & numerical data
MH  - Female
MH  - Fetal Death/immunology/pathology/*prevention & control
MH  - Fetal Growth Retardation/mortality/pathology/*prevention & control
MH  - Fetal Monitoring/methods/mortality
MH  - Lipopolysaccharides/*antagonists & inhibitors/*toxicity
MH  - Male
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Pregnancy
MH  - Premature Birth/mortality/pathology/prevention & control
MH  - Random Allocation
MH  - Zinc/*administration & dosage/therapeutic use
EDAT- 2012/06/05 06:00
MHDA- 2012/09/08 06:00
CRDT- 2012/06/05 06:00
PHST- 2012/06/05 06:00 [entrez]
PHST- 2012/06/05 06:00 [pubmed]
PHST- 2012/09/08 06:00 [medline]
AID - jimmunol.1103579 [pii]
AID - 10.4049/jimmunol.1103579 [doi]
PST - ppublish
SO  - J Immunol. 2012 Jul 1;189(1):454-63. doi: 10.4049/jimmunol.1103579. Epub 2012 Jun 
      1.