PMID- 22661255
OWN - NLM
STAT- MEDLINE
DCOM- 20130830
LR  - 20161020
IS  - 1439-7609 (Electronic)
IS  - 1439-7595 (Linking)
VI  - 23
IP  - 2
DP  - 2013 Mar
TI  - Association between transforming growth factor-alpha polymorphism and ankylosing 
      spondylitis: a meta-analysis update.
PG  - 334-44
LID - 10.1007/s10165-012-0659-0 [doi]
AB  - OBJECTIVES: The reported results of the relationship between genetic 
      polymorphisms of tumor necrosis factor (TNF)-alpha -238, -308 locus and ankylosing 
      spondylitis (AS) susceptibility are not always consistent. This article aims to 
      perform a meta-analysis to collect all the relevant studies to date to further 
      clarify the relationship between those genetic polymorphisms and AS. METHODS: A 
      computer search was carried out up to September 2011 for literature pertaining to 
      AS and TNF-alpha polymorphisms. RESULTS: Twenty-two articles were included, with 
      2,506 cases of AS and 3,023 normal controls. We searched for genotypes A allele 
      vs. G allele, AA vs. GG + GA, and GA + AA vs. GG in a fixed/random-effects model. 
      The effect summary odds ratios (ORs) and 95 % confidence intervals (CIs) were 
      obtained, which shows there was no association between genetic polymorphisms and 
      AS. As the heterogeneity was observed, in a subgroup analysis by ethnicity, the 
      degree of risk of two genes with AS susceptibility was similar in populations of 
      European and Asian origin. For the human leukocyte antigen (HLA)-B27+ population, 
      results were not statistically significant. CONCLUSION: ORs of various 
      comparisons indicate that there is no association between TNF-alpha -238, -308 
      polymorphisms and AS susceptibility in the overall population and in the subgroup 
      of Asian and non-Asian descent.
FAU - Wang, Chencheng
AU  - Wang C
AD  - Epidemiology and Biostatistics School of Public Health, Anhui Medical University, 
      Hefei 230032, China. smbzfdbxsandy@sina.com
FAU - Su, Hong
AU  - Su H
FAU - Chang, Weiwei
AU  - Chang W
FAU - Xu, Zhiwei
AU  - Xu Z
FAU - Han, Qin
AU  - Han Q
FAU - Shan, Xiaowei
AU  - Shan X
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
DEP - 20120602
PL  - England
TA  - Mod Rheumatol
JT  - Modern rheumatology
JID - 100959226
RN  - 0 (Transforming Growth Factor alpha)
SB  - IM
MH  - Alleles
MH  - Genetic Association Studies
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - *Polymorphism, Single Nucleotide
MH  - Spondylitis, Ankylosing/*genetics
MH  - Transforming Growth Factor alpha/*genetics
EDAT- 2012/06/05 06:00
MHDA- 2013/08/31 06:00
CRDT- 2012/06/05 06:00
PHST- 2011/09/20 00:00 [received]
PHST- 2012/04/16 00:00 [accepted]
PHST- 2012/06/05 06:00 [entrez]
PHST- 2012/06/05 06:00 [pubmed]
PHST- 2013/08/31 06:00 [medline]
AID - 10.1007/s10165-012-0659-0 [doi]
PST - ppublish
SO  - Mod Rheumatol. 2013 Mar;23(2):334-44. doi: 10.1007/s10165-012-0659-0. Epub 2012 
      Jun 2.