PMID- 22661465
OWN - NLM
STAT- MEDLINE
DCOM- 20120918
LR  - 20220331
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Linking)
VI  - 53
IP  - 7
DP  - 2012 Jun 28
TI  - En face enhanced depth imaging optical coherence tomography of fibrovascular 
      pigment epithelium detachment.
PG  - 4147-51
LID - 10.1167/iovs.12-9878 [doi]
AB  - PURPOSE: To analyze the internal structure of fibrovascular pigment epithelial 
      detachment (FV-PED) due to AMD using en face enhanced depth imaging (EDI) 
      spectral-domain optical coherence tomography (SD-OCT). METHODS: Thirty-eight 
      consecutive patients presenting with FV-PED due to AMD were enrolled in this 
      study. Retinal images were automatically obtained with a spectral domain (SD) OCT 
      instrument; the typical inverted 97 sections at 30-mum intervals, each comprised 
      of nine averaged B-scans, were acquired in less than 60 seconds. The resultant 
      images of en face cross-sections of the choroid (C-scans) were compared with 
      indocyanine green angiography (ICGA) images, currently the only technique 
      available for directly viewing occult choroidal neovascularization (CNV). 
      RESULTS: Thirty-eight eyes of 38 consecutive patients (27 females and 11 males, 
      mean age 76.7+/-3 years) were studied. In all 38 eyes, ICGA allowed visualization 
      of the CNV within the FV-PED. In 30 eyes, en face EDI-OCT revealed what appeared 
      to be the hyperreflective course of presumed CNV, which was located just beneath 
      the detached retinal pigment epithelium; this was confirmed by comparative 
      analysis of the extent of hyperreflective lesions on en face EDI-OCT images and 
      that of the neovascular network on ICGA. An area of homogeneous hyporeflectivity, 
      consistent with serous exudation, separated the CNV from the Bruch's membrane and 
      the choroid. In the remaining eight eyes, en face EDI-OCT revealed homogenous 
      hyperreflectivity, consistent with fibrous tissue that partially hid the 
      neovascular network. CONCLUSIONS: Noninvasive en face EDI-OCT technique enables 
      visualization and localization of the entire branching neovascular network of CNV 
      within FV-PED without dye injection.
FAU - Coscas, Florence
AU  - Coscas F
AD  - Department of Ophthalmology, University Paris Est Creteil, Centre Hospitalier 
      Intercommunal de Creteil, Creteil, France.
FAU - Coscas, Gabriel
AU  - Coscas G
FAU - Querques, Giuseppe
AU  - Querques G
FAU - Massamba, Nathalie
AU  - Massamba N
FAU - Querques, Lea
AU  - Querques L
FAU - Bandello, Francesco
AU  - Bandello F
FAU - Souied, Eric H
AU  - Souied EH
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20120628
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
SB  - IM
MH  - Aged
MH  - Diagnosis, Differential
MH  - Female
MH  - Fluorescein Angiography
MH  - Follow-Up Studies
MH  - Fundus Oculi
MH  - Humans
MH  - *Image Enhancement
MH  - Male
MH  - Reproducibility of Results
MH  - Retinal Detachment/etiology/*pathology
MH  - Retinal Neovascularization/*complications/pathology
MH  - Retinal Pigment Epithelium/*pathology
MH  - Retrospective Studies
MH  - Tomography, Optical Coherence/*methods
EDAT- 2012/06/05 06:00
MHDA- 2012/09/19 06:00
CRDT- 2012/06/05 06:00
PHST- 2012/06/05 06:00 [entrez]
PHST- 2012/06/05 06:00 [pubmed]
PHST- 2012/09/19 06:00 [medline]
AID - iovs.12-9878 [pii]
AID - 10.1167/iovs.12-9878 [doi]
PST - epublish
SO  - Invest Ophthalmol Vis Sci. 2012 Jun 28;53(7):4147-51. doi: 10.1167/iovs.12-9878.