PMID- 22661990
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 1896-9151 (Electronic)
IS  - 1734-1922 (Print)
IS  - 1734-1922 (Linking)
VI  - 8
IP  - 2
DP  - 2012 May 9
TI  - The effect of adhesive strength of hydroxyapatite coating on the stability of 
      hydroxyapatite-coated prostheses in vivo at the early stage of implantation.
PG  - 199-208
LID - 10.5114/aoms.2012.28545 [doi]
AB  - INTRODUCTION: With the increase in joint revision surgery after arthroplasty, 
      defects of hydroxyapatite (HA)-coated prostheses have been observed increasingly 
      often. These defects adversely affect the prosthetic stability in vivo. This 
      study has analyzed the potential effect of the adhesive strength of HA coating on 
      the stability of HA-coated prostheses in vivo after its implantation. MATERIAL 
      AND METHODS: Sixty experimental rabbits were divided into HA- and Ti-coated 
      groups. HA-coated prostheses were implanted into the bilateral epicondyle of 
      rabbits femurs. Ti-coated prostheses were implanted as control. At different time 
      points(4, 9, and 15 weeks) after implantation, bone tissue samples were fetched 
      out respectively for histomorphometric analysis. Push-out testing was used to 
      detect the ultimate shear strength at the bone-prosthesis interface. Scanning 
      electron microscope (SEM) observation and energy-dispersive X-ray spectroscopy 
      (EDX) analysis were used to observe the changes in surface composition of the 
      prostheses after the ultimate shear strength testing. The coating adhesive 
      strength of two kinds of coatings were also examined by scratch testing. RESULTS: 
      Hydroxyapatite coating has an obvious advantage in facilitating osteogenesis and 
      its plays a critical role in the stability of prostheses. However, the ultimate 
      shear strength of HA-coated prostheses is much lower than that of Ti-coated 
      implants (p < 0.01). Further study has demonstrated that the stability of 
      HA-coated prostheses in vivo is affected by the relatively low adhesive strength 
      between coating and substrate. CONCLUSIONS: Obvious advantage in facilitating 
      osteogenesis around HA-coated prostheses is not the only factor that determines 
      the stability of prostheses in vivo.
FAU - Duan, Yonghong
AU  - Duan Y
AD  - Orthopedic Institute of Chinese People's Liberation Army, Xijing Hospital, Fourth 
      Military Medical University, Xi'an, Shanxi, China.
FAU - Zhu, Shu
AU  - Zhu S
FAU - Guo, Fei
AU  - Guo F
FAU - Zhu, Jinyu
AU  - Zhu J
FAU - Li, Mao
AU  - Li M
FAU - Ma, Jie
AU  - Ma J
FAU - Zhu, Qingsheng
AU  - Zhu Q
LA  - eng
PT  - Journal Article
PL  - Poland
TA  - Arch Med Sci
JT  - Archives of medical science : AMS
JID - 101258257
PMC - PMC3361030
OTO - NOTNLM
OT  - adhesive strength
OT  - artificial joints
OT  - biomechanical
OT  - hydroxyapatite coating
OT  - stability
EDAT- 2012/06/05 06:00
MHDA- 2012/06/05 06:01
PMCR- 2012/05/09
CRDT- 2012/06/05 06:00
PHST- 2011/01/12 00:00 [received]
PHST- 2011/03/22 00:00 [revised]
PHST- 2011/06/11 00:00 [accepted]
PHST- 2012/06/05 06:00 [entrez]
PHST- 2012/06/05 06:00 [pubmed]
PHST- 2012/06/05 06:01 [medline]
PHST- 2012/05/09 00:00 [pmc-release]
AID - 18544 [pii]
AID - 10.5114/aoms.2012.28545 [doi]
PST - ppublish
SO  - Arch Med Sci. 2012 May 9;8(2):199-208. doi: 10.5114/aoms.2012.28545.