PMID- 22664136
OWN - NLM
STAT- MEDLINE
DCOM- 20130408
LR  - 20221207
IS  - 1879-0046 (Electronic)
IS  - 0376-8716 (Print)
IS  - 0376-8716 (Linking)
VI  - 126
IP  - 1-2
DP  - 2012 Nov 1
TI  - Contrasting effects of d-methamphetamine, 3,4-methylenedioxymethamphetamine, 
      3,4-methylenedioxypyrovalerone, and 4-methylmethcathinone on wheel activity in 
      rats.
PG  - 168-75
LID - S0376-8716(12)00174-3 [pii]
LID - 10.1016/j.drugalcdep.2012.05.011 [doi]
AB  - BACKGROUND: Reports from U.S., U.K. and European drug policy entities, and 
      ongoing media accounts, show increasing recreational use of 4-methylmethcathinone 
      (4-MMC, mephedrone) and 3,4-methylenedioxypyrovalerone (MDPV). Severe 
      sympathomimetic symptoms, hallucinations, psychoses, and even deaths have been 
      reported, yet little scientific information is available on the effects of these 
      compounds in laboratory models. Available studies on the neurochemistry of these 
      drugs show that 4-MMC and MDPV enhance DA neurotransmission, while 4-MMC 
      additionally enhances 5-HT neurotransmission--a pattern much like that reported 
      for methamphetamine versus 3,4-methylenedioxymethamphetamine (MDMA). As is the 
      case for designer amphetamines, these neurochemical distinctions may predict 
      differential potential for repetitive versus episodic abuse and distinct lasting 
      toxicities. METHODS: This study determined relative locomotor stimulant effects 
      of 4-MMC (1-10 mg/kg, s.c.) and MDPV (0.5-5.6 mg/kg, s.c.), in comparison with 
      d-methamphetamine (MA; 0.5-5.6 mg/kg, s.c.) and MDMA (1-7.5 mg/kg, s.c.) on a 
      measure of locomotor activity--voluntary wheel running--in male Wistar rats 
      (N=8). RESULTS: Compared to counts of wheel rotations after saline, a biphasic 
      change in the pattern of counts was observed after injections of MA and MDPV, 
      with relatively higher counts following lower doses and lower counts following 
      the highest dose. However, monophasic, dose-dependent reductions in counts were 
      observed in response to injections of MDMA and 4-MMC. CONCLUSION: Thus, voluntary 
      wheel running yielded the same categorical distinctions for these drugs as did 
      prior experiments testing the effects of these drugs on monoaminergic 
      neurotransmission. These data indicate that MDPV produces prototypical locomotor 
      stimulant effects whereas 4-MMC is more similar to the entactogen MDMA.
CI  - Copyright (c) 2012 Elsevier Ireland Ltd. All rights reserved.
FAU - Huang, Pai-Kai
AU  - Huang PK
AD  - Committee on the Neurobiology of Addictive Disorders, The Scripps Research 
      Institute, CA 92037, USA.
FAU - Aarde, Shawn M
AU  - Aarde SM
FAU - Angrish, Deepshikha
AU  - Angrish D
FAU - Houseknecht, Karen L
AU  - Houseknecht KL
FAU - Dickerson, Tobin J
AU  - Dickerson TJ
FAU - Taffe, Michael A
AU  - Taffe MA
LA  - eng
GR  - DA024705/DA/NIDA NIH HHS/United States
GR  - R01 DA024705/DA/NIDA NIH HHS/United States
GR  - R01 DA024105/DA/NIDA NIH HHS/United States
GR  - R01 DA018418/DA/NIDA NIH HHS/United States
GR  - DA024105/DA/NIDA NIH HHS/United States
GR  - DA018418/DA/NIDA NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20120603
PL  - Ireland
TA  - Drug Alcohol Depend
JT  - Drug and alcohol dependence
JID - 7513587
RN  - 0 (Benzodioxoles)
RN  - 0 (Central Nervous System Stimulants)
RN  - 0 (Designer Drugs)
RN  - 0 (Hallucinogens)
RN  - 0 (Pyrrolidines)
RN  - 44RAL3456C (Methamphetamine)
RN  - 8BA8T27317 (mephedrone)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - TZ47U051FI (Dextroamphetamine)
RN  - 0 (Synthetic Cathinone)
SB  - IM
MH  - Animals
MH  - Benzodioxoles/*pharmacology
MH  - Central Nervous System Stimulants/*pharmacology
MH  - Data Interpretation, Statistical
MH  - Designer Drugs/*pharmacology
MH  - Dextroamphetamine/*pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Hallucinogens/*pharmacology
MH  - Male
MH  - Methamphetamine/*analogs & derivatives/pharmacology
MH  - Motor Activity/*drug effects
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*pharmacology
MH  - Pyrrolidines/*pharmacology
MH  - Rats
MH  - Rats, Wistar
MH  - Stimulation, Chemical
MH  - Synthetic Cathinone
PMC - PMC3439532
MID - NIHMS378818
EDAT- 2012/06/06 06:00
MHDA- 2013/04/09 06:00
PMCR- 2013/11/01
CRDT- 2012/06/06 06:00
PHST- 2012/03/14 00:00 [received]
PHST- 2012/05/10 00:00 [revised]
PHST- 2012/05/11 00:00 [accepted]
PHST- 2012/06/06 06:00 [entrez]
PHST- 2012/06/06 06:00 [pubmed]
PHST- 2013/04/09 06:00 [medline]
PHST- 2013/11/01 00:00 [pmc-release]
AID - S0376-8716(12)00174-3 [pii]
AID - 10.1016/j.drugalcdep.2012.05.011 [doi]
PST - ppublish
SO  - Drug Alcohol Depend. 2012 Nov 1;126(1-2):168-75. doi: 
      10.1016/j.drugalcdep.2012.05.011. Epub 2012 Jun 3.