PMID- 22664754
OWN - NLM
STAT- MEDLINE
DCOM- 20121217
LR  - 20190819
IS  - 1347-4820 (Electronic)
IS  - 1346-9843 (Linking)
VI  - 76
IP  - 8
DP  - 2012
TI  - Effects of machine-assisted cycling on exercise capacity and endothelial function 
      in elderly patients with heart failure.
PG  - 1889-94
AB  - BACKGROUND: Conventional exercise training (ET) for elderly patients with heart 
      failure (HF) includes low-intensity stretching and gait training. The effects of 
      2 types of low-intensity ET - machine-assisted cycling and conventional ET - on 
      exercise capacity and endothelial function of elderly patients with HF was 
      investigated in the present study. METHODS AND RESULTS: Twenty-seven elderly 
      patients with HF (mean age: 79.5 years) were randomly assigned to either a 
      machine-assisted cycling group or a conventional ET group. At baseline and after 
      2 weeks of ET, all patients were tested for 6-minute walk distance (6MWD) and 
      digital reactive hyperemia-peripheral arterial tonometry (RH-PAT). After 2 weeks 
      of ET, a significant increase in 6MWD was observed in both groups with no 
      significant difference between the groups. RH-PAT index significantly increased 
      in patients aged </=80 (1.55+/-0.33 to 1.93+/-0.62, P=0.035) and a trend toward 
      increase in RH-PAT index in the machine-assisted cycling group was observed 
      (1.59+/-0.52 to 1.93+/-0.63, P=0.053), although no change was observed in the 
      conventional ET group. In the multivariate model, patients' age and 
      machine-assisted cycling were associated with the increases in RH-PAT index 
      (P<0.05). CONCLUSIONS: Machine-assisted cycling appeared to be as effective as 
      conventional ET on exercise capacity in elderly patients with HF. Additionally, 
      machine-assisted cycling has the potential to improve endothelial function in 
      these patients.
FAU - Ozasa, Neiko
AU  - Ozasa N
AD  - Department of Cardiovascular Medicine, Kyoto University Graduate School of 
      Medicine, Kyoto, Japan. nei126@kuhp.kyoto-u.ac.jp
FAU - Morimoto, Takeshi
AU  - Morimoto T
FAU - Bao, Bingyuan
AU  - Bao B
FAU - Shioi, Tetsuo
AU  - Shioi T
FAU - Kimura, Takeshi
AU  - Kimura T
LA  - eng
SI  - ClinicalTrials.gov/NCT00733161
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20120516
PL  - Japan
TA  - Circ J
JT  - Circulation journal : official journal of the Japanese Circulation Society
JID - 101137683
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Endothelium, Vascular/*physiopathology
MH  - *Exercise
MH  - Female
MH  - Heart Failure/*physiopathology/*therapy
MH  - Humans
MH  - Male
MH  - *Resistance Training
EDAT- 2012/06/06 06:00
MHDA- 2012/12/18 06:00
CRDT- 2012/06/06 06:00
PHST- 2012/06/06 06:00 [entrez]
PHST- 2012/06/06 06:00 [pubmed]
PHST- 2012/12/18 06:00 [medline]
AID - DN/JST.JSTAGE/circj/CJ-11-1113 [pii]
AID - 10.1253/circj.cj-11-1113 [doi]
PST - ppublish
SO  - Circ J. 2012;76(8):1889-94. doi: 10.1253/circj.cj-11-1113. Epub 2012 May 16.