PMID- 22665336
OWN - NLM
STAT- MEDLINE
DCOM- 20121003
LR  - 20220321
IS  - 1976-2437 (Electronic)
IS  - 0513-5796 (Print)
IS  - 0513-5796 (Linking)
VI  - 53
IP  - 4
DP  - 2012 Jul 1
TI  - The clinical characteristics of steroid responsive nephrotic syndrome of children 
      according to the serum immunoglobulin E levels and cytokines.
PG  - 715-22
LID - 10.3349/ymj.2012.53.4.715 [doi]
AB  - PURPOSE: The nephrotic syndrome (NS) is characterized by the favorable response 
      to glucocorticoid therapy and the development of NS may be associated with 
      dysfunctional immune systems. In order to investigate the serum immunoglobulin E 
      (IgE) levels and cytokines activity in pediatric NS, the total of 32 steroid 
      responsive NS patients and 5 healthy controls were enrolled in this study. 
      MATERIALS AND METHODS: All patients were divided into two groups according to the 
      initial serum IgE levels, such as normal and high IgE group, and their clinical 
      characteristics were evaluated. In addition, serum levels of interleukin (IL)-4, 
      IL-5, IL-10 and transforming growth factor (TGF)-beta were compared and correlated 
      with serum albumin, proteinuria by means of disease severity, and cytokines. 
      RESULTS: In the high IgE group, the higher comorbidity of allergic diseases and 
      relapsing rate, the longer duration of steroid therapy before initial remission, 
      and the higher serum IL-4 and IL-5 levels were found. In all patients, initially 
      higher serum levels of IL-4 and IL-5 declined to normal levels after steroid 
      therapy, whereas the serum IL-10 levels showed no significant difference between 
      nephrotic phase (heavy proteinuria) and remission phase (no proteinuria) of NS. 
      The serum TGF-beta levels of the nephrotic phase were significantly lower than those 
      of remission phase or control group, and returned to normal control levels after 
      steroid therapy. CONCLUSION: This study indicates that initial IgE level is 
      associated with steroid responsiveness and disease severity, and cytokine 
      activities may also be related to the pathogenesis of pediatric steroid 
      responsive NS.
FAU - Youn, You Sook
AU  - Youn YS
AD  - Department of Pediatrics, Deajeon St. Mary's Hospital, The Catholic University of 
      Korea, Daejeon, Korea.
FAU - Lim, Han Hyuk
AU  - Lim HH
FAU - Lee, Jae Ho
AU  - Lee JH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Korea (South)
TA  - Yonsei Med J
JT  - Yonsei medical journal
JID - 0414003
RN  - 0 (Cytokines)
RN  - 0 (Immunoglobulin A)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Immunoglobulin M)
RN  - 0 (Interleukin-5)
RN  - 0 (Steroids)
RN  - 0 (Transforming Growth Factor beta)
RN  - 207137-56-2 (Interleukin-4)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Child, Preschool
MH  - Cytokines/*blood
MH  - Female
MH  - Humans
MH  - Immunoglobulin A/blood
MH  - Immunoglobulin E/*blood
MH  - Immunoglobulin G/blood
MH  - Immunoglobulin M/blood
MH  - Infant
MH  - Interleukin-4/blood
MH  - Interleukin-5/blood
MH  - Male
MH  - Nephrotic Syndrome/*blood/*drug therapy
MH  - Steroids/*therapeutic use
MH  - Transforming Growth Factor beta/blood
PMC - PMC3381495
COIS- The authors have no financial conflicts of interest.
EDAT- 2012/06/06 06:00
MHDA- 2012/10/04 06:00
PMCR- 2012/07/01
CRDT- 2012/06/06 06:00
PHST- 2012/06/06 06:00 [entrez]
PHST- 2012/06/06 06:00 [pubmed]
PHST- 2012/10/04 06:00 [medline]
PHST- 2012/07/01 00:00 [pmc-release]
AID - 201207715 [pii]
AID - 10.3349/ymj.2012.53.4.715 [doi]
PST - ppublish
SO  - Yonsei Med J. 2012 Jul 1;53(4):715-22. doi: 10.3349/ymj.2012.53.4.715.