PMID- 22665518
OWN - NLM
STAT- MEDLINE
DCOM- 20120924
LR  - 20211203
IS  - 1540-8140 (Electronic)
IS  - 0021-9525 (Print)
IS  - 0021-9525 (Linking)
VI  - 197
IP  - 6
DP  - 2012 Jun 11
TI  - Smooth muscle-endothelial cell communication activates Reelin signaling and 
      regulates lymphatic vessel formation.
PG  - 837-49
LID - 10.1083/jcb.201110132 [doi]
AB  - Active lymph transport relies on smooth muscle cell (SMC) contractions around 
      collecting lymphatic vessels, yet regulation of lymphatic vessel wall assembly 
      and lymphatic pumping are poorly understood. Here, we identify Reelin, an 
      extracellular matrix glycoprotein previously implicated in central nervous system 
      development, as an important regulator of lymphatic vascular development. 
      Reelin-deficient mice showed abnormal collecting lymphatic vessels, characterized 
      by a reduced number of SMCs, abnormal expression of lymphatic capillary marker 
      lymphatic vessel endothelial hyaluronan receptor 1 (LYVE-1), and impaired 
      function. Furthermore, we show that SMC recruitment to lymphatic vessels 
      stimulated release and proteolytic processing of endothelium-derived Reelin. 
      Lymphatic endothelial cells in turn responded to Reelin by up-regulating monocyte 
      chemotactic protein 1 (MCP1) expression, which suggests an autocrine mechanism 
      for Reelin-mediated control of endothelial factor expression upstream of SMC 
      recruitment. These results uncover a mechanism by which Reelin signaling is 
      activated by communication between the two cell types of the collecting lymphatic 
      vessels--smooth muscle and endothelial cells--and highlight a hitherto 
      unrecognized and important function for SMCs in lymphatic vessel morphogenesis 
      and function.
FAU - Lutter, Sophie
AU  - Lutter S
AD  - Lymphatic Development Laboratory, Cancer Research UK London Research Institute, 
      London WC2A 3LY, England, UK.
FAU - Xie, Sherry
AU  - Xie S
FAU - Tatin, Florence
AU  - Tatin F
FAU - Makinen, Taija
AU  - Makinen T
LA  - eng
GR  - Cancer Research UK/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120604
PL  - United States
TA  - J Cell Biol
JT  - The Journal of cell biology
JID - 0375356
RN  - 0 (Cell Adhesion Molecules, Neuronal)
RN  - 0 (Extracellular Matrix Proteins)
RN  - 0 (LYVE1 protein, human)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Platelet Endothelial Cell Adhesion Molecule-1)
RN  - 0 (Reelin Protein)
RN  - 0 (Vesicular Transport Proteins)
RN  - EC 3.4.21.- (RELN protein, human)
RN  - EC 3.4.21.- (Reln protein, mouse)
RN  - EC 3.4.21.- (Serine Endopeptidases)
SB  - IM
MH  - Animals
MH  - Cell Adhesion Molecules, Neuronal/genetics/*metabolism
MH  - Cell Communication
MH  - Cell Movement
MH  - Cells, Cultured
MH  - Endothelium, Vascular/*metabolism
MH  - Extracellular Matrix Proteins/genetics/*metabolism
MH  - Humans
MH  - Lymphatic Vessels/*metabolism
MH  - Mice
MH  - Mice, Inbred Strains
MH  - Myocytes, Smooth Muscle/*metabolism
MH  - Nerve Tissue Proteins/genetics/*metabolism
MH  - Platelet Endothelial Cell Adhesion Molecule-1/metabolism
MH  - Reelin Protein
MH  - Serine Endopeptidases/genetics/*metabolism
MH  - *Signal Transduction
MH  - Vesicular Transport Proteins/genetics/metabolism
PMC - PMC3373399
EDAT- 2012/06/06 06:00
MHDA- 2012/09/25 06:00
PMCR- 2012/12/11
CRDT- 2012/06/06 06:00
PHST- 2012/06/06 06:00 [entrez]
PHST- 2012/06/06 06:00 [pubmed]
PHST- 2012/09/25 06:00 [medline]
PHST- 2012/12/11 00:00 [pmc-release]
AID - jcb.201110132 [pii]
AID - 201110132 [pii]
AID - 10.1083/jcb.201110132 [doi]
PST - ppublish
SO  - J Cell Biol. 2012 Jun 11;197(6):837-49. doi: 10.1083/jcb.201110132. Epub 2012 Jun 
      4.