PMID- 22667101
OWN - NLM
STAT- MEDLINE
DCOM- 20130712
LR  - 20190923
IS  - 1000-8713 (Print)
IS  - 1000-8713 (Linking)
VI  - 30
IP  - 1
DP  - 2012 Jan
TI  - [Determination of residual organic solvents in flunixin meglumine raw material by 
      headspace gas chromatography].
PG  - 99-102
AB  - A method for the determination of five kinds of residual organic solvents in 
      flunixin meglumine raw material was developed by headspace gas chromatography. An 
      HP-FFAP capillary column (30 m x 0.32 mm x 1.0 microm), a flame ionization 
      detector and the external standard method were used for the separation and 
      quantitative analysis. The effects of equilibrium temperature and equilibrium 
      time on the determination of residual organic solvents were investigated. The 
      good results were obtained in the equilibrium temperature of 90 degrees C and 
      equilibrium time of 30 min. The standard curves were linear in the range of 
      0.40-7.93 mg/L (r = 0.999 8) for ethyl acetate, 7.32-146.48 mg/L (r = 0.999 6) 
      for methanol, 4.53-90.61 mg/L (r = 0.999 9) for isopropanol, 3.62-72.32 mg/L (r = 
      0.999 8) for ethanol and 2.31-46.24 mg/L (r = 0.999 6) for acetonitrile. The 
      recoveries for the five residual organic solvents were between 95.96% and 100.31% 
      with relative standard deviations (RSDs) (n = 6) of 1.97%-3.28%. The detection 
      limits of ethyl acetate, methanol, isopropanol, ethanol and acetonitrile were 
      0.08, 0.9, 0.2, 0.4 and 0.3 mg/L, respectively. The proposed method was 
      successfully applied to analyze the residual organic solvents in the real sample 
      of flunixin meglumine raw material. The results showed that only isopropanol and 
      ethanol were found in the sample with the contents of 177.44 microg/g and 69.32 
      microg/g, respectively. The method is rapid, sensitive and accurate for the 
      content determination of residual solvents in flunixin meglumine raw material.
FAU - Hu, Huilian
AU  - Hu H
AD  - Research Center of Analysis and Testing, East China University of Science and 
      Technology, Shanghai 200237, China. huhl@ecust.edu.cn
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Se Pu
JT  - Se pu = Chinese journal of chromatography
JID - 9424804
RN  - 0 (Acetates)
RN  - 0 (Solvents)
RN  - 3K9958V90M (Ethanol)
RN  - 76845O8NMZ (ethyl acetate)
RN  - 8Y3JK0JW3U (flunixin meglumine)
RN  - ND2M416302 (2-Propanol)
RN  - V7DXN0M42R (Clonixin)
RN  - Y4S76JWI15 (Methanol)
SB  - IM
MH  - 2-Propanol/analysis/isolation & purification
MH  - Acetates/analysis/isolation & purification
MH  - Chromatography, Gas/*methods
MH  - Clonixin/*analogs & derivatives/chemistry
MH  - *Drug Contamination
MH  - Ethanol/analysis/isolation & purification
MH  - Methanol/analysis/isolation & purification
MH  - Solvents/*analysis/isolation & purification
EDAT- 2012/06/07 06:00
MHDA- 2013/07/16 06:00
CRDT- 2012/06/07 06:00
PHST- 2012/06/07 06:00 [entrez]
PHST- 2012/06/07 06:00 [pubmed]
PHST- 2013/07/16 06:00 [medline]
AID - 10.3724/sp.j.1123.2011.09009 [doi]
PST - ppublish
SO  - Se Pu. 2012 Jan;30(1):99-102. doi: 10.3724/sp.j.1123.2011.09009.