PMID- 22667691
OWN - NLM
STAT- MEDLINE
DCOM- 20121113
LR  - 20181201
IS  - 1520-5827 (Electronic)
IS  - 0743-7463 (Linking)
VI  - 28
IP  - 26
DP  - 2012 Jul 3
TI  - Controlling the stability and size of double-emulsion-templated 
      poly(lactic-co-glycolic) acid microcapsules.
PG  - 9944-52
LID - 10.1021/la301498f [doi]
AB  - The stability and size of poly(lactic-co-glycolic)acid (PLGA)-containing double 
      emulsions and the resulting PLGA microcapsules are controlled by varying the 
      composition of highly monodisperse water-in-oil-in-water (W/O/W) double 
      emulsions. We propose that the basic inner phase of W/O/W double emulsions 
      catalyzes the hydrolysis of PLGA and the ionization of carboxylic acid end 
      groups, which enhances the surface activity of PLGA and facilitates the 
      stabilization of the double emulsions. The size of PLGA-containing double 
      emulsions and that of resulting microcapsules can be readily tuned by osmotic 
      annealing, which depends on the concentration ratio of a solute in the inner and 
      outer phases of double emulsions. The internal volume of PLGA microcapsules can 
      be changed by more than 3 orders of magnitude using this method. This approach 
      also overcomes the difficulty in generating monodisperse double emulsions and 
      microcapsules over a wide range of dimensions using a single microfluidic device. 
      The osmotic annealing method can also be used to concentrate encapsulated species 
      such as colloidal suspensions and biomacromolecules.
FAU - Tu, Fuquan
AU  - Tu F
AD  - Department of Chemical and Biomolecular Engineering, University of Pennsylvania, 
      Philadelphia, Pennsylvania 19104, United States.
FAU - Lee, Daeyeon
AU  - Lee D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20120622
PL  - United States
TA  - Langmuir
JT  - Langmuir : the ACS journal of surfaces and colloids
JID - 9882736
RN  - 0 (Capsules)
RN  - 0 (Emulsions)
RN  - 059QF0KO0R (Water)
RN  - 1SIA8062RS (Polylactic Acid-Polyglycolic Acid Copolymer)
RN  - 26009-03-0 (Polyglycolic Acid)
RN  - 33X04XA5AT (Lactic Acid)
SB  - IM
MH  - Capsules
MH  - Emulsions
MH  - Hydrogen-Ion Concentration
MH  - Lactic Acid/*chemistry
MH  - Osmotic Pressure
MH  - Polyglycolic Acid/*chemistry
MH  - Polylactic Acid-Polyglycolic Acid Copolymer
MH  - Water/chemistry
EDAT- 2012/06/07 06:00
MHDA- 2012/11/14 06:00
CRDT- 2012/06/07 06:00
PHST- 2012/06/07 06:00 [entrez]
PHST- 2012/06/07 06:00 [pubmed]
PHST- 2012/11/14 06:00 [medline]
AID - 10.1021/la301498f [doi]
PST - ppublish
SO  - Langmuir. 2012 Jul 3;28(26):9944-52. doi: 10.1021/la301498f. Epub 2012 Jun 22.