PMID- 2266778
OWN - NLM
STAT- MEDLINE
DCOM- 19910208
LR  - 20190701
IS  - 0024-3205 (Print)
IS  - 0024-3205 (Linking)
VI  - 47
IP  - 21
DP  - 1990
TI  - The effect of cholinergic manipulations on the analgesic response to cobrotoxin 
      in mice.
PG  - 1949-54
AB  - Intracerebroventricular (i.c.v.) injection of cobrotoxin (CT), a neurotoxin 
      isolated from the venom of Naja naja atra, produced an antinociceptive response 
      in mice as measured by the tail-flick test. This effect of CT was blocked by 
      systemic administration of atropine, but not by methylatropine or naloxone. 
      Depletion of central acetylcholine (ACh) by hemicholinium-3 (HC-3) blocked the 
      antinociceptive action of cobrotoxin. These results suggest that central 
      cholinergic neurons are important for the mediation of the antinociceptive 
      properties of cobrotoxin.
FAU - Chen, R Z
AU  - Chen RZ
AD  - Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia 
      Commonwealth University, Richmond 23298-0613.
FAU - Robinson, S E
AU  - Robinson SE
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Life Sci
JT  - Life sciences
JID - 0375521
RN  - 0 (Atropine Derivatives)
RN  - 0 (Cobra Neurotoxin Proteins)
RN  - 0 (Parasympatholytics)
RN  - 7C0697DR9I (Atropine)
RN  - 80719I460H (methylatropine)
RN  - N9YNS0M02X (Acetylcholine)
SB  - IM
MH  - Acetylcholine/*physiology
MH  - Analgesia
MH  - Animals
MH  - Atropine/pharmacology
MH  - Atropine Derivatives/pharmacology
MH  - Cholinergic Fibers/drug effects/physiology
MH  - Cobra Neurotoxin Proteins/administration & dosage/*pharmacology
MH  - Injections, Intraventricular
MH  - Male
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Neurons/drug effects/physiology
MH  - Nociceptors/drug effects/physiology
MH  - Pain Measurement/methods
MH  - Parasympatholytics/pharmacology
EDAT- 1990/01/01 00:00
MHDA- 1990/01/01 00:01
CRDT- 1990/01/01 00:00
PHST- 1990/01/01 00:00 [pubmed]
PHST- 1990/01/01 00:01 [medline]
PHST- 1990/01/01 00:00 [entrez]
AID - 0024-3205(90)90407-I [pii]
AID - 10.1016/0024-3205(90)90407-i [doi]
PST - ppublish
SO  - Life Sci. 1990;47(21):1949-54. doi: 10.1016/0024-3205(90)90407-i.