PMID- 22668980
OWN - NLM
STAT- MEDLINE
DCOM- 20140521
LR  - 20220330
IS  - 1536-481X (Electronic)
IS  - 1057-0829 (Linking)
VI  - 22
IP  - 9
DP  - 2013 Dec
TI  - Ability of optical coherence tomography-determined ganglion cell complex 
      thickness to total retinal thickness ratio to diagnose glaucoma.
PG  - 757-62
LID - 10.1097/IJG.0b013e31825af58a [doi]
AB  - PURPOSE: To evaluate the usefulness of the spectral-domain optical coherence 
      tomography (SD OCT)-determined ganglion cell complex thickness to total retinal 
      thickness ratio (G/T ratio) in diagnosing glaucoma. METHODS: A total of 99 eyes 
      with primary open-angle glaucoma and 35 normal eyes were enrolled in the study. 
      SD OCT (RTVue-100) was used to measure the macular ganglion cell complex 
      thickness, total retinal thickness, outer retinal thickness, and circumpapillary 
      retinal nerve fiber layer (RNFL) thickness. A new macular parameter, the G/T 
      ratio, was also calculated. The ability of each parameter to diagnose glaucoma 
      was examined by analyzing the area under the receiver operating characteristics 
      curve (AUROC) and the sensitivity at fixed specificity. RESULTS: The G/T ratio 
      was 36.0 +/- 1.5% in normal eyes, 31.8 +/- 1.7% in early glaucoma, and 30.2 +/- 2.6% in 
      advanced glaucoma. These decreases in the ratio were statistically significant. 
      For the AUROC, the individual SD OCT parameters were 0.982 for the G/T ratio, 
      0.968 for the macular ganglion cell complex thickness, 0.942 for the RNFL 
      thickness, and 0.841 for the total retinal thickness. The AUROC for the G/T ratio 
      was significantly higher than that seen for the total retinal and RNFL 
      thicknesses (P<0.05). Analyses of the sensitivity at a specificity of >90% 
      indicated that the G/T ratio (sensitivity, 93.94%) was the best diagnostic 
      parameter. CONCLUSIONS: Decreases in the G/T ratio occur during the early stages 
      of glaucoma. When using SD OCT to diagnose glaucoma, the G/T ratio may improve 
      the diagnostic ability of the macular parameter.
FAU - Kita, Yoshiyuki
AU  - Kita Y
AD  - *Department of Ophthalmology, Toho University Ohashi Medical Center daggerDepartment 
      of Medical Informatics, Toho University School of Medicine, Tokyo, Japan.
FAU - Kita, Ritsuko
AU  - Kita R
FAU - Takeyama, Asuka
AU  - Takeyama A
FAU - Takagi, Seiji
AU  - Takagi S
FAU - Nishimura, Chiaki
AU  - Nishimura C
FAU - Tomita, Goji
AU  - Tomita G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Glaucoma
JT  - Journal of glaucoma
JID - 9300903
SB  - IM
MH  - Female
MH  - Glaucoma, Open-Angle/*diagnosis
MH  - Humans
MH  - Intraocular Pressure
MH  - Male
MH  - Middle Aged
MH  - Nerve Fibers/*pathology
MH  - ROC Curve
MH  - Retina/*pathology
MH  - Retinal Ganglion Cells/*pathology
MH  - Sensitivity and Specificity
MH  - Tomography, Optical Coherence/*methods
MH  - Tonometry, Ocular
EDAT- 2012/06/07 06:00
MHDA- 2014/05/23 06:00
CRDT- 2012/06/07 06:00
PHST- 2012/06/07 06:00 [entrez]
PHST- 2012/06/07 06:00 [pubmed]
PHST- 2014/05/23 06:00 [medline]
AID - 10.1097/IJG.0b013e31825af58a [doi]
PST - ppublish
SO  - J Glaucoma. 2013 Dec;22(9):757-62. doi: 10.1097/IJG.0b013e31825af58a.