PMID- 22670171
OWN - NLM
STAT- MEDLINE
DCOM- 20121010
LR  - 20220331
IS  - 1936-2625 (Electronic)
IS  - 1936-2625 (Linking)
VI  - 5
IP  - 4
DP  - 2012
TI  - Aldo-keto reductase family 1 member C3 (AKR1C3) is expressed in adenocarcinoma 
      and squamous cell carcinoma but not small cell carcinoma.
PG  - 278-89
AB  - Human aldo-keto reductase family 1 member C3 (AKR1C3) was initially identified as 
      a critical enzyme in reducing 5alpha-dihydrotestosterone (5alpha-DHT) to 
      5alpha-androstane-3alpha,17beta-diol (3alpha-diol) and oxidizing 3alpha-diol to androsterone. Based 
      on these enzymatic activities, AKR1C3 was originally named type 2 
      3alpha-hydroxysteroid dehydrogenase (HSD)/type 5 17beta-HSD. Additionally, AKR1C3 was 
      demonstrated to be capable of metabolizing other steroids including estrogen and 
      progesterone. Subsequently, AKR1C3 was shown to possess 11-ketoprostaglandin 
      reductase activity in metabolizing prostaglandins and dihydrodiol dehydrogenase x 
      (DDx) activity in metabolizing xenobiotics. Tissue distribution of AKR1C3 has 
      been detected in both sex hormone-dependent organs such as the testis, breast, 
      endometrium, and prostate as well as sex hormone-independent organs including the 
      kidney and urothelium. Although prominent expression of AKR1C isozymes has been 
      reported in human non-small cell lung carcinoma (NSCLC), the expression of AKR1C3 
      in small cell carcinoma of the lung has not been described. Also, the expression 
      of AKR1C3 in normal lung has not been described. In this study, we demonstrated 
      strong AKR1C3 immunoreactivity in bronchial epithelium but not in bronchial 
      glands or alveolar pneumocytes. Strong AKR1C3 immunoreactivity was also 
      demonstrated in columnar epithelium but only weak immunoreactivity in squamous 
      epithelium of the gastrointestinal junction. Although AKR1C3 immunoreactivity was 
      absent in small cell carcinoma of the lung, positive AKR1C3 immunoreactivity was 
      extensively present in both adenocarcinoma and squamous cell carcinoma arising 
      from the lung and the gastroesophageal junction. AKR1C3 may serve as an adjunct 
      marker for differentiating small cell carcinoma from NSCLC. However, roles of 
      AKR1C3 in adenocarcinoma, squamous cell carcinoma, and small cell carcinoma 
      pathogenesis require further studies.
FAU - Miller, Valerie L
AU  - Miller VL
AD  - College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma 
      City, OK 73104, USA.
FAU - Lin, Hsueh-Kung
AU  - Lin HK
FAU - Murugan, Paari
AU  - Murugan P
FAU - Fan, Michael
AU  - Fan M
FAU - Penning, Trevor M
AU  - Penning TM
FAU - Brame, Lacy S
AU  - Brame LS
FAU - Yang, Qing
AU  - Yang Q
FAU - Fung, Kar-Ming
AU  - Fung KM
LA  - eng
GR  - P30 ES013508/ES/NIEHS NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20120426
PL  - United States
TA  - Int J Clin Exp Pathol
JT  - International journal of clinical and experimental pathology
JID - 101480565
RN  - 0 (Biomarkers, Tumor)
RN  - EC 1.1.- (3-Hydroxysteroid Dehydrogenases)
RN  - EC 1.1.1.- (Hydroxyprostaglandin Dehydrogenases)
RN  - EC 1.1.1.357 (AKR1C3 protein, human)
RN  - EC 1.1.1.357 (Aldo-Keto Reductase Family 1 Member C3)
SB  - IM
MH  - 3-Hydroxysteroid Dehydrogenases/*analysis
MH  - Adenocarcinoma/*enzymology/pathology
MH  - Adenocarcinoma of Lung
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Aldo-Keto Reductase Family 1 Member C3
MH  - Biomarkers, Tumor/*analysis
MH  - Carcinoma, Squamous Cell/*enzymology/pathology
MH  - Diagnosis, Differential
MH  - Esophageal Neoplasms/*enzymology/pathology
MH  - Esophagogastric Junction/*enzymology/pathology
MH  - Female
MH  - Humans
MH  - Hydroxyprostaglandin Dehydrogenases/*analysis
MH  - Immunohistochemistry
MH  - Lung Neoplasms/*enzymology/pathology
MH  - Male
MH  - Middle Aged
MH  - Oklahoma
MH  - Predictive Value of Tests
MH  - Small Cell Lung Carcinoma/*enzymology/pathology
MH  - Stomach Neoplasms/*enzymology/pathology
PMC - PMC3365826
OTO - NOTNLM
OT  - AKR1C3
OT  - adenocarcinoma
OT  - esophagus
OT  - gastroesophageal junction
OT  - lung
OT  - non-small cell carcinoma
OT  - small cell carcinoma
OT  - squamous cell carcinoma
OT  - stomach
EDAT- 2012/06/07 06:00
MHDA- 2012/10/12 06:00
PMCR- 2012/04/26
CRDT- 2012/06/07 06:00
PHST- 2012/03/23 00:00 [received]
PHST- 2012/04/16 00:00 [accepted]
PHST- 2012/06/07 06:00 [entrez]
PHST- 2012/06/07 06:00 [pubmed]
PHST- 2012/10/12 06:00 [medline]
PHST- 2012/04/26 00:00 [pmc-release]
PST - ppublish
SO  - Int J Clin Exp Pathol. 2012;5(4):278-89. Epub 2012 Apr 26.