PMID- 22670643
OWN - NLM
STAT- MEDLINE
DCOM- 20121026
LR  - 20190115
IS  - 1365-3083 (Electronic)
IS  - 0300-9475 (Linking)
VI  - 76
IP  - 3
DP  - 2012 Sep
TI  - Green tea (Camelia sinensis) mediated suppression of IgE production by peripheral 
      blood mononuclear cells of allergic asthmatic humans.
PG  - 306-10
LID - 10.1111/j.1365-3083.2012.02729.x [doi]
AB  - Recent studies in our laboratory demonstrated the suppression of immunoglobulin E 
      (IgE) production by green tea extract (GTE) in U266 cells. However, the effects 
      of GTE or one of its components (EGCG) on IgE production by human peripheral 
      blood mononuclear cells (PBMC) are unknown. PBMC (1.5 x 10(6)) obtained from serum 
      IgE+, allergic asthmatic patients, were cultured +/- GTE (1-100 ng/ml) or purified 
      EGCG (0.5-50 ng/ml), and IgE levels were determined on day 10 by enzyme-linked 
      immunosorbent assay (ELISA). High levels of IgE were detected in supernatants of 
      the PBMC cultures on day 10. When GTE was included in vitro, IgE production by 
      PBMC was suppressed on day 10, compared with control. Purified EGCG included in 
      vitro also suppressed IgE production, but at lower levels, compared with control. 
      This study demonstrates that GTE and its major catechin, EGCG, have 
      immunoregulatory effects on human IgE responses.
CI  - (c) 2012 The Authors. Scandinavian Journal of Immunology (c) 2012 Blackwell 
      Publishing Ltd.
FAU - Wu, S Y
AU  - Wu SY
AD  - Department of Medicine, State University of New York Downstate Medical Center, 
      Brooklyn, NY, USA.
FAU - Silverberg, J I
AU  - Silverberg JI
FAU - Joks, R
AU  - Joks R
FAU - Durkin, H G
AU  - Durkin HG
FAU - Smith-Norowitz, T A
AU  - Smith-Norowitz TA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Scand J Immunol
JT  - Scandinavian journal of immunology
JID - 0323767
RN  - 0 (Plant Extracts)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 632XD903SP (Gallic Acid)
RN  - O97U9TPY8V (epigallocatechin-3-O-(3''-O-methyl)-gallate)
SB  - IM
MH  - Adult
MH  - Asthma/*immunology
MH  - *Camellia sinensis
MH  - Cells, Cultured
MH  - Female
MH  - Gallic Acid/analogs & derivatives/pharmacology
MH  - Humans
MH  - Immunoglobulin E/*biosynthesis
MH  - Leukocytes, Mononuclear/*drug effects
MH  - Male
MH  - Middle Aged
MH  - Phytotherapy
MH  - Plant Extracts/*pharmacology
EDAT- 2012/06/08 06:00
MHDA- 2012/10/27 06:00
CRDT- 2012/06/08 06:00
PHST- 2012/06/08 06:00 [entrez]
PHST- 2012/06/08 06:00 [pubmed]
PHST- 2012/10/27 06:00 [medline]
AID - 10.1111/j.1365-3083.2012.02729.x [doi]
PST - ppublish
SO  - Scand J Immunol. 2012 Sep;76(3):306-10. doi: 10.1111/j.1365-3083.2012.02729.x.