PMID- 22670776
OWN - NLM
STAT- MEDLINE
DCOM- 20120820
LR  - 20211021
IS  - 1365-2249 (Electronic)
IS  - 0009-9104 (Print)
IS  - 0009-9104 (Linking)
VI  - 169
IP  - 1
DP  - 2012 Jul
TI  - Intravenous immunoglobulin does not increase FcgammaRIIB expression levels on 
      monocytes in children with immune thrombocytopenia.
PG  - 33-7
LID - 10.1111/j.1365-2249.2012.04591.x [doi]
AB  - Intravenous immunoglobulin (IVIG) produces a rapid and prolonged increase in the 
      platelet counts of children with immune thrombocytopenia (ITP). The mechanism of 
      IVIG efficacy in a murine model of ITP has been reported to operate through an 
      IVIG-mediated increase in the expression of the inhibitory Fc receptor 
      FcgammaRIIB(CD32B) on splenic macrophages. This investigation examined whether IVIG 
      administration results in a similar increase in FcgammaRIIB expression on peripheral 
      blood CD14(+) monocytes in 20 children with ITP. FcgammaRIIB expression on peripheral 
      blood monocytes was measured by flow cytometry in ITP patients, before and after 
      IVIG therapy, as well as in control subjects. Peripheral blood monocytes were 
      labelled with fluorescent-specific antibodies. There were no significant 
      differences in the absolute number of [corrected] CD14(+) CD32B(+) monocytes, and 
      [corrected] the percentages of CD14(+) CD32B(+) cells in mononuclear cells or 
      monocytes. [corrected]. We suggest that IVIG does not increase FcgammaRIIB expression 
      in peripheral blood monocytes in children with ITP.
CI  - (c) 2012 The Authors. Clinical and Experimental Immunology (c) 2012 British Society 
      for Immunology.
FAU - Shimomura, M
AU  - Shimomura M
AD  - Department of Pediatrics, Yamaguchi University Graduate School of Medicine, Ube, 
      Japan. r004um@yamaguchi-u.ac.jp
FAU - Hasegawa, S
AU  - Hasegawa S
FAU - Seki, Y
AU  - Seki Y
FAU - Fukano, R
AU  - Fukano R
FAU - Hotta, N
AU  - Hotta N
FAU - Ichiyama, T
AU  - Ichiyama T
LA  - eng
PT  - Journal Article
PL  - England
TA  - Clin Exp Immunol
JT  - Clinical and experimental immunology
JID - 0057202
RN  - 0 (FCGR3B protein, human)
RN  - 0 (Fc gamma receptor IIB)
RN  - 0 (GPI-Linked Proteins)
RN  - 0 (Immunoglobulins, Intravenous)
RN  - 0 (Lipopolysaccharide Receptors)
RN  - 0 (Receptors, IgG)
SB  - IM
EIN - Clin Exp Immunol. 2014 Aug;177(2):554
MH  - Acute Disease
MH  - Animals
MH  - Case-Control Studies
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Flow Cytometry
MH  - GPI-Linked Proteins/blood/immunology
MH  - Humans
MH  - Immunoglobulins, Intravenous/*administration & dosage
MH  - Infant
MH  - Lipopolysaccharide Receptors/blood/immunology
MH  - Macrophages/immunology
MH  - Male
MH  - Mice
MH  - Monocytes/*immunology
MH  - Platelet Count
MH  - Receptors, IgG/biosynthesis/*blood/immunology
MH  - Thrombocytopenia/*immunology
PMC - PMC3390471
EDAT- 2012/06/08 06:00
MHDA- 2012/08/21 06:00
PMCR- 2013/07/01
CRDT- 2012/06/08 06:00
PHST- 2012/06/08 06:00 [entrez]
PHST- 2012/06/08 06:00 [pubmed]
PHST- 2012/08/21 06:00 [medline]
PHST- 2013/07/01 00:00 [pmc-release]
AID - 10.1111/j.1365-2249.2012.04591.x [doi]
PST - ppublish
SO  - Clin Exp Immunol. 2012 Jul;169(1):33-7. doi: 10.1111/j.1365-2249.2012.04591.x.