PMID- 2267138
OWN - NLM
STAT- MEDLINE
DCOM- 19910214
LR  - 20151119
IS  - 0950-9232 (Print)
IS  - 0950-9232 (Linking)
VI  - 5
IP  - 11
DP  - 1990 Nov
TI  - Increased retinoblastoma gene expression is associated with late stages of 
      differentiation in many different cell types.
PG  - 1731-3
AB  - The retinoblastoma (Rb) gene is a recessive oncogene or tumor-suppressor gene 
      whose inactivation leads to the development of tumors. Recently, evidence 
      pointing to a role for the Rb gene in the differentiation of certain human cell 
      types has been presented. We have studied three mouse cell lineages to determine 
      whether there is a correlation between Rb gene expression and differentiation. We 
      find that induction of mouse erythroleukemia cell differentiation with either 
      dimethylsulfoxide (DMSO) or hexamethylene bisacetamide (HMBA) leads to increased 
      expression of Rb mRNA. Increased expression of Rb mRNA was also found in S2 
      myoblasts induced by mitogen depletion to become differentiated myotubes. In the 
      B-cell lineage, Rb expression is low in pre-B and B cell lines but high in 
      plasmacytomas, which represent late stages of B cell differentiation. Thus, in 
      all three lineages (erythroid, muscle, and B-cell) late stages of differentiation 
      are associated with increased amounts of Rb mRNA.
FAU - Coppola, J A
AU  - Coppola JA
AD  - Department of Biology, Princeton University, New Jersey 08544-1014.
FAU - Lewis, B A
AU  - Lewis BA
FAU - Cole, M D
AU  - Cole MD
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Oncogene
JT  - Oncogene
JID - 8711562
RN  - 0 (Acetamides)
RN  - 0 (RNA, Messenger)
RN  - LA133J59VU (hexamethylene bisacetamide)
RN  - YOW8V9698H (Dimethyl Sulfoxide)
SB  - IM
MH  - Acetamides/pharmacology
MH  - Animals
MH  - B-Lymphocytes/metabolism/pathology
MH  - Cell Differentiation/drug effects
MH  - Dimethyl Sulfoxide/pharmacology
MH  - Embryo, Mammalian
MH  - *Gene Expression
MH  - Genes, Retinoblastoma/*genetics
MH  - Kinetics
MH  - Leukemia, Erythroblastic, Acute/metabolism/pathology
MH  - Mice
MH  - Muscles/cytology/metabolism
MH  - Phosphorylation
MH  - Plasmacytoma/metabolism
MH  - RNA, Messenger/biosynthesis/genetics
MH  - Tumor Cells, Cultured
EDAT- 1990/11/01 00:00
MHDA- 1990/11/01 00:01
CRDT- 1990/11/01 00:00
PHST- 1990/11/01 00:00 [pubmed]
PHST- 1990/11/01 00:01 [medline]
PHST- 1990/11/01 00:00 [entrez]
PST - ppublish
SO  - Oncogene. 1990 Nov;5(11):1731-3.