PMID- 22672201
OWN - NLM
STAT- MEDLINE
DCOM- 20130524
LR  - 20140529
IS  - 1399-3062 (Electronic)
IS  - 1398-2273 (Linking)
VI  - 14
IP  - 6
DP  - 2012 Dec
TI  - Pre-transplant myeloid dendritic cell deficiency associated with cytomegalovirus 
      infection and death after kidney transplantation.
PG  - 618-25
LID - 10.1111/j.1399-3062.2012.00750.x [doi]
AB  - BACKGROUND: Dendritic cells (DCs) are potent antigen-presenting cells critical 
      for immunity. We previously demonstrated a significant association between 
      pre-transplant blood myeloid dendritic cell (mDC) and plasmacytoid dendritic cell 
      (pDC) deficiency and post-transplant BK viremia in renal transplant recipients. 
      In the current post-hoc analysis, we studied the association of these same 
      pre-transplant DC levels with other post-transplant outcomes. METHODS: 
      Pre-transplant peripheral blood mDC and pDC levels were quantified using flow 
      cytometry in 78 patients undergoing kidney transplantation. Post-transplant 
      outcomes were analyzed, including infection, rejection, and patient death, with a 
      median follow-up of 5.3 years. Associations between DC levels and outcomes were 
      assessed using logistic regression analysis and Cox proportional hazards models. 
      RESULTS: An independent association of mDC levels with post-transplant 
      cytomegalovirus infection (adjusted odds ratio 7.0, P = 0.01) and patient death 
      (adjusted hazard ratio 13.0, P = 0.015) was found. No associations were 
      demonstrated between levels of either DC subtype and bacterial infections or 
      rejection. CONCLUSIONS: Pre-transplant mDC deficiency is significantly associated 
      with CMV infection and death after kidney transplantation.
CI  - (c) 2012 John Wiley & Sons A/S.
FAU - Sun, Q
AU  - Sun Q
AD  - Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, 
      Maryland, USA.
FAU - Hall, E C
AU  - Hall EC
FAU - Huang, Y
AU  - Huang Y
FAU - Chen, P
AU  - Chen P
FAU - Dibadj, K
AU  - Dibadj K
FAU - Murawski, M
AU  - Murawski M
FAU - Shraybman, R
AU  - Shraybman R
FAU - Van Kirk, K
AU  - Van Kirk K
FAU - Tang, V
AU  - Tang V
FAU - Peng, R
AU  - Peng R
FAU - Patton, P R
AU  - Patton PR
FAU - Clare-Salzler, M J
AU  - Clare-Salzler MJ
FAU - Kaplan, B
AU  - Kaplan B
FAU - Segev, D L
AU  - Segev DL
FAU - Womer, K L
AU  - Womer KL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120606
PL  - Denmark
TA  - Transpl Infect Dis
JT  - Transplant infectious disease : an official journal of the Transplantation 
      Society
JID - 100883688
SB  - IM
MH  - Adult
MH  - Cytomegalovirus Infections/*etiology/*mortality
MH  - Dendritic Cells/*physiology
MH  - Female
MH  - Humans
MH  - Kidney Transplantation/*adverse effects/mortality
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Odds Ratio
MH  - Risk Factors
EDAT- 2012/06/08 06:00
MHDA- 2013/05/28 06:00
CRDT- 2012/06/08 06:00
PHST- 2011/07/29 00:00 [received]
PHST- 2011/11/01 00:00 [revised]
PHST- 2012/01/21 00:00 [accepted]
PHST- 2012/06/08 06:00 [entrez]
PHST- 2012/06/08 06:00 [pubmed]
PHST- 2013/05/28 06:00 [medline]
AID - 10.1111/j.1399-3062.2012.00750.x [doi]
PST - ppublish
SO  - Transpl Infect Dis. 2012 Dec;14(6):618-25. doi: 10.1111/j.1399-3062.2012.00750.x. 
      Epub 2012 Jun 6.