PMID- 22672302
OWN - NLM
STAT- MEDLINE
DCOM- 20121019
LR  - 20231011
IS  - 1755-5949 (Electronic)
IS  - 1755-5930 (Print)
IS  - 1755-5930 (Linking)
VI  - 18
IP  - 6
DP  - 2012 Jun
TI  - NPY intraperitoneal injections produce antidepressant-like effects and 
      downregulate BDNF in the rat hypothalamus.
PG  - 487-92
LID - 10.1111/j.1755-5949.2012.00314.x [doi]
AB  - AIMS: Several studies have documented an involvement of Neuropeptide Y (NPY) in 
      stress-related disorders. Stress-related disorders are also characterized by 
      changes in brain-derived neurotrophic factor (BDNF) and nerve growth factor 
      (NGF), neurotrophins implicated in the survival and function of neurons. Thus the 
      aim of this study was to investigate whether an NPY intraperitoneal treatment has 
      antidepressant-like effects in rats subjected to a classical stress paradigm, the 
      Forced Swim Test (FST), in association with changes in local brain neurotrophin 
      production. METHODS: Rats were intraperitoneally injected with either NPY (60 
      mug/kg) or a vehicle for three consecutive days between two FST sessions and then 
      tested for time spent (or delay onset) in immobile posture. Moreover, we measured 
      by enzyme-linked immunosorbent assay (ELISA) neurotrophin levels in the 
      hypothalamus and corticosterone levels in plasma. RESULTS: The data showed that 
      NPY induced a significant delay in the onset and a significant reduction in the 
      duration of the immobility posture in FST. We also found that NPY decreased BDNF 
      levels in the hypothalamus and corticosterone levels in plasma. DISCUSSION: 
      Immobility posture in FST can be reduced by antidepressant drugs. Thus, our data 
      show an antidepressant-like effect of NPY associated with changes in BDNF levels 
      in the hypothalamus and reduced activity of hypothalamic-pituitary-adrenal (HPA) 
      axis. CONCLUSION: These findings, while confirming the involvement of the NPY 
      system in stress-related disorders, suggest that a less invasive route of 
      administration, such as an intraperitoneal injection, may be instrumental in 
      coping with stressful events in animal models and perhaps in humans.
CI  - (c) 2012 Blackwell Publishing Ltd.
FAU - Gelfo, Francesca
AU  - Gelfo F
AD  - Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, 
      Rome, Italy.
FAU - Tirassa, Paola
AU  - Tirassa P
FAU - De Bartolo, Paola
AU  - De Bartolo P
FAU - Croce, Nicoletta
AU  - Croce N
FAU - Bernardini, Sergio
AU  - Bernardini S
FAU - Caltagirone, Carlo
AU  - Caltagirone C
FAU - Petrosini, Laura
AU  - Petrosini L
FAU - Angelucci, Francesco
AU  - Angelucci F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - CNS Neurosci Ther
JT  - CNS neuroscience & therapeutics
JID - 101473265
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Neuropeptide Y)
RN  - 9061-61-4 (Nerve Growth Factor)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Antidepressive Agents/*administration & dosage
MH  - Body Weight/drug effects
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Corticosterone/blood
MH  - *Depression/drug therapy/metabolism/pathology
MH  - Disease Models, Animal
MH  - Down-Regulation/*drug effects
MH  - Eating/drug effects
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Hypothalamus/*metabolism
MH  - Male
MH  - Nerve Growth Factor/metabolism
MH  - Neuropeptide Y/*administration & dosage
MH  - Rats
MH  - Rats, Wistar
MH  - Swimming/psychology
MH  - Time Factors
PMC - PMC6493532
COIS- The authors declare no conflict of interest.
EDAT- 2012/06/08 06:00
MHDA- 2012/10/20 06:00
PMCR- 2012/06/04
CRDT- 2012/06/08 06:00
PHST- 2012/06/08 06:00 [entrez]
PHST- 2012/06/08 06:00 [pubmed]
PHST- 2012/10/20 06:00 [medline]
PHST- 2012/06/04 00:00 [pmc-release]
AID - CNS314 [pii]
AID - 10.1111/j.1755-5949.2012.00314.x [doi]
PST - ppublish
SO  - CNS Neurosci Ther. 2012 Jun;18(6):487-92. doi: 10.1111/j.1755-5949.2012.00314.x.