PMID- 22673097
OWN - NLM
STAT- MEDLINE
DCOM- 20130507
LR  - 20161125
IS  - 1532-818X (Electronic)
IS  - 0196-0709 (Linking)
VI  - 33
IP  - 6
DP  - 2012 Nov-Dec
TI  - Videofluorographic detection of anti-muscle-specific kinase-positive myasthenia 
      gravis.
PG  - 758-61
LID - S0196-0709(12)00083-X [pii]
LID - 10.1016/j.amjoto.2012.04.003 [doi]
AB  - A 47-year-old woman with dysphagia and ptosis gradually developed dysarthria and 
      muscular weakness. Magnetic resonance imaging, testing for anti-acetylcholine 
      receptor antibodies, edrophonium chloride (EC) test, and electrophysiologic test 
      revealed no abnormalities. A psychogenic reaction was suspected. Four months 
      after disease onset, the patient presented to our hospital. In videofluoroscopic 
      examination of swallowing (VF), there was no aspiration for swallowing of either 
      liquid or soft food. It revealed, however, poor pharyngeal constriction, no 
      epiglottis inversion, repeated swallowing movements, and large amounts of 
      pharyngeal residue. Videofluoroscopic examination of swallowing after an 
      intravenous injection of 10 mg EC showed improvements in all above observations; 
      particularly, it was clear when swallowing soft food. Furthermore, the 
      anti-muscle-specific kinase (MuSK) antibody titer was elevated, and anti-MuSK 
      antibody-positive myasthenia gravis (MuSK-MG) was diagnosed. Thus VF during EC 
      test may be helpful in diagnosing MuSK-MG in patients with dysphagia.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Yamamoto, Toshiyuki
AU  - Yamamoto T
AD  - Department of Neurology, National Center Hospital of Neurology and Psychiatry, 
      Tokyo, Japan. yamamoto@ncnp.go.jp
FAU - Chihara, Norio
AU  - Chihara N
FAU - Mori-Yoshimura, Madoka
AU  - Mori-Yoshimura M
FAU - Murata, Miho
AU  - Murata M
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20120604
PL  - United States
TA  - Am J Otolaryngol
JT  - American journal of otolaryngology
JID - 8000029
RN  - 0 (Autoantibodies)
RN  - 0 (Receptors, Cholinergic)
RN  - EC 2.7.10.1 (MUSK protein, human)
RN  - EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases)
SB  - IM
MH  - Autoantibodies/*blood
MH  - Diagnosis, Differential
MH  - Female
MH  - Fluoroscopy/*methods
MH  - Humans
MH  - Middle Aged
MH  - Myasthenia Gravis/*diagnostic imaging/immunology
MH  - Receptor Protein-Tyrosine Kinases/*immunology
MH  - Receptors, Cholinergic/*immunology
MH  - *Videotape Recording
EDAT- 2012/06/08 06:00
MHDA- 2013/05/08 06:00
CRDT- 2012/06/08 06:00
PHST- 2012/03/19 00:00 [received]
PHST- 2012/04/13 00:00 [accepted]
PHST- 2012/06/08 06:00 [entrez]
PHST- 2012/06/08 06:00 [pubmed]
PHST- 2013/05/08 06:00 [medline]
AID - S0196-0709(12)00083-X [pii]
AID - 10.1016/j.amjoto.2012.04.003 [doi]
PST - ppublish
SO  - Am J Otolaryngol. 2012 Nov-Dec;33(6):758-61. doi: 10.1016/j.amjoto.2012.04.003. 
      Epub 2012 Jun 4.