PMID- 22673601
OWN - NLM
STAT- MEDLINE
DCOM- 20130301
LR  - 20190907
IS  - 1348-4540 (Electronic)
IS  - 0918-8959 (Linking)
VI  - 59
IP  - 9
DP  - 2012
TI  - Delay in the diagnosis of multiple endocrine neoplasia type 1: typical symptoms 
      are frequently overlooked.
PG  - 797-807
AB  - The morbidity and mortality of individuals with multiple endocrine neoplasia type 
      1 (MEN1) can be reduced by early diagnosis of MEN1 and related endocrine tumors. 
      To find factors contributing to early diagnosis, we collected clinical 
      information on MEN1 patients through a MEN study group, "MEN Consortium of Japan" 
      and analyzed the time of initial symptom-dependent detection of parathyroid 
      tumors, gastro-entero-pancreatic neuroendocrine tumors (GEPNETs) and pituitary 
      tumors, and that of tumor detection-dependent MEN1 diagnosis in 560 patients. 
      Main tumors were identified up to 7.0 years after symptoms appeared and there was 
      no difference in age at the diagnosis of GEPNETs alone between probands and 
      family members. In patients with typical symptoms (peptic ulcers, urolithiasis, 
      fasting hypoglycemia, bone fracture/loss and amenorrhea), the mean interval 
      between symptom manifestation and tumor detection was extended up to 9.6 years. 
      In particular, 21.7% (5/23) of patients with amenorrhea were diagnosed with 
      pituitary tumors in under one year. In patients with peptic ulcers (from 
      parathyroid tumors or GEPNETs) and urolithiasis (from parathyroid tumors), the 
      interval was positively correlated with age at tumor detection. The interval 
      between tumor detection and MEN1 diagnosis was also prolonged to approximately 
      four years in patients with fasting hypoglycemia (from GEPNETs) and amenorrhea. A 
      substantial delay in the diagnosis of symptom-related tumors and subsequent MEN1 
      and inadequate screening of GEPNETs in family members were indicated. A greater 
      understanding of MEN1 may assist medical practitioners to make earlier diagnoses, 
      to share patients' medical information and to give family members sufficient 
      disease information.
FAU - Yamazaki, Masanori
AU  - Yamazaki M
AD  - Division of Diabetes, Endocrinology and Metabolism, Department of Internal 
      Medicine, Shinshu University School of Medicine, Matsumoto 390-8621, Japan.
FAU - Suzuki, Shin-ichi
AU  - Suzuki S
FAU - Kosugi, Shinji
AU  - Kosugi S
FAU - Okamoto, Takahiro
AU  - Okamoto T
FAU - Uchino, Shinya
AU  - Uchino S
FAU - Miya, Akihiro
AU  - Miya A
FAU - Imai, Tsuneo
AU  - Imai T
FAU - Kaji, Hiroshi
AU  - Kaji H
FAU - Komoto, Izumi
AU  - Komoto I
FAU - Miura, Daishu
AU  - Miura D
FAU - Yamada, Masanobu
AU  - Yamada M
FAU - Uruno, Takashi
AU  - Uruno T
FAU - Horiuchi, Kiyomi
AU  - Horiuchi K
FAU - Sato, Ai
AU  - Sato A
FAU - Miyauchi, Akira
AU  - Miyauchi A
FAU - Imamura, Masayuki
AU  - Imamura M
FAU - Sakurai, Akihiro
AU  - Sakurai A
CN  - MEN Consortium of Japan
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120603
PL  - Japan
TA  - Endocr J
JT  - Endocrine journal
JID - 9313485
SB  - IM
MH  - Age of Onset
MH  - Amenorrhea/etiology
MH  - Databases, Factual
MH  - *Delayed Diagnosis/prevention & control
MH  - Family Health
MH  - Female
MH  - Humans
MH  - Hypoglycemia/etiology
MH  - Japan/epidemiology
MH  - Male
MH  - Multiple Endocrine Neoplasia Type 1/*diagnosis/epidemiology/*physiopathology
MH  - Osteoporotic Fractures/etiology
MH  - Peptic Ulcer/etiology
MH  - Urolithiasis/etiology
FIR - Fukushima, Toshihiko
IR  - Fukushima T
FIR - Hanazaki, Kazuhiro
IR  - Hanazaki K
FIR - Hirakawa, Shohei
IR  - Hirakawa S
FIR - Igarashi, Takehito
IR  - Igarashi T
FIR - Iwatani, Tsuguo
IR  - Iwatani T
FIR - Kammori, Makoto
IR  - Kammori M
FIR - Katabami, Takuyuki
IR  - Katabami T
FIR - Katai, Miyuki
IR  - Katai M
FIR - Kikumori, Toyone
IR  - Kikumori T
FIR - Kiribayashi, Kazuyo
IR  - Kiribayashi K
FIR - Shigeki, Koizumi
IR  - Shigeki K
FIR - Midorikawa, Sanae
IR  - Midorikawa S
FIR - Miyabe, Rika
IR  - Miyabe R
FIR - Munekage, Takuya
IR  - Munekage T
FIR - Ozawa, Atsushi
IR  - Ozawa A
FIR - Shimizu, Kazuo
IR  - Shimizu K
FIR - Sugitani, Iwao
IR  - Sugitani I
FIR - Takeyama, Hiroshi
IR  - Takeyama H
EDAT- 2012/06/08 06:00
MHDA- 2013/03/02 06:00
CRDT- 2012/06/08 06:00
PHST- 2012/06/08 06:00 [entrez]
PHST- 2012/06/08 06:00 [pubmed]
PHST- 2013/03/02 06:00 [medline]
AID - DN/JST.JSTAGE/endocrj/EJ12-0071 [pii]
AID - 10.1507/endocrj.ej12-0071 [doi]
PST - ppublish
SO  - Endocr J. 2012;59(9):797-807. doi: 10.1507/endocrj.ej12-0071. Epub 2012 Jun 3.