PMID- 2267410
OWN - NLM
STAT- MEDLINE
DCOM- 19910211
LR  - 20191022
IS  - 0923-2494 (Print)
IS  - 0923-2494 (Linking)
VI  - 141
IP  - 4-5
DP  - 1990 May-Jun
TI  - Anti-beta 2-microglobulin monoclonal antibodies mediate a delay in HIV1 
      cytopathic effect on MT4 cells.
PG  - 357-72
AB  - We attempted to select monoclonal antibodies (mAb) which reacted with T-cell 
      surface molecules and were able to interfere with the human immunodeficiency 
      virus type 1 (HIV1) replicative cycle in the MT4 T-leukaemic cell line. In 
      comparison with OKT4A, an anti-CD4 mAb, only one mAb, HC11.151.1, was found to 
      significantly delay HIV-induced cytopathic effect on MT4 cells among the 15 mAb 
      tested which reacted with MT4 cell surface antigens. Biochemical and 
      immunological characterization of HC11.151.1 demonstrated its specificity for 
      beta 2-microglobulin (beta 2m), the light chain of human leukocyte antigen (HLA) 
      class I molecules. Other beta 2m-specific mAb were tested in order to assess 
      whether this effect represented an intrinsic capacity of HC11.151.1 or whether it 
      was a common feature shared by all anti-beta 2m mAb. Three (B1.1G6, B2.62.2 and 
      BBM1) of the four anti-beta 2m mAb demonstrated the same protective effect, 
      whereas C21.48A, which was devoid of a functional effect, was directed towards a 
      beta 2m epitope involved in binding to the HLA class I heavy chain molecule. The 
      physiological relevance of this observation is discussed.
FAU - Devaux, C
AU  - Devaux C
AD  - INSERM-U322, Unite de Recherches sur les Retrovirus et Maladies Associees, 
      Marseille, France.
FAU - Boucraut, J
AU  - Boucraut J
FAU - Poirier, G
AU  - Poirier G
FAU - Corbeau, P
AU  - Corbeau P
FAU - Rey, F
AU  - Rey F
FAU - Benkirane, M
AU  - Benkirane M
FAU - Perarnau, B
AU  - Perarnau B
FAU - Kourilsky, F
AU  - Kourilsky F
FAU - Chermann, J C
AU  - Chermann JC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - France
TA  - Res Immunol
JT  - Research in immunology
JID - 8907467
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (CD4 Antigens)
RN  - 0 (beta 2-Microglobulin)
SB  - IM
MH  - Antibodies, Monoclonal
MH  - CD4 Antigens
MH  - Cell Line
MH  - Cytopathogenic Effect, Viral/physiology
MH  - HIV-1/*pathogenicity/physiology
MH  - Humans
MH  - Virus Replication
MH  - beta 2-Microglobulin/antagonists & inhibitors/immunology/*physiology
EDAT- 1990/05/01 00:00
MHDA- 1990/05/01 00:01
CRDT- 1990/05/01 00:00
PHST- 1990/05/01 00:00 [pubmed]
PHST- 1990/05/01 00:01 [medline]
PHST- 1990/05/01 00:00 [entrez]
AID - 0923-2494(90)90026-U [pii]
AID - 10.1016/0923-2494(90)90026-u [doi]
PST - ppublish
SO  - Res Immunol. 1990 May-Jun;141(4-5):357-72. doi: 10.1016/0923-2494(90)90026-u.