PMID- 22674266
OWN - NLM
STAT- MEDLINE
DCOM- 20120809
LR  - 20220309
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Print)
IS  - 0270-6474 (Linking)
VI  - 32
IP  - 23
DP  - 2012 Jun 6
TI  - Activity regulates functional connectivity from the vomeronasal organ to the 
      accessory olfactory bulb.
PG  - 7907-16
LID - 10.1523/JNEUROSCI.2399-11.2012 [doi]
AB  - The mammalian accessory olfactory system is specialized for the detection of 
      chemicals that identify kin and conspecifics. Vomeronasal sensory neurons (VSNs) 
      residing in the vomeronasal organ project axons to the accessory olfactory bulb 
      (AOB), where they form synapses with principal neurons known as mitral cells. The 
      organization of this projection is quite precise and is believed to be essential 
      for appropriate function of this system. However, how this precise connectivity 
      is established is unknown. We show here that in mice the vomeronasal duct is open 
      at birth, allowing external chemical stimuli access to sensory neurons, and that 
      these sensory neurons are capable of releasing neurotransmitter to downstream 
      neurons as early as the first postnatal day (P). Using major histocompatibility 
      complex class I peptides to activate a selective subset of VSNs during the first 
      few postnatal days of development, we show that increased activity results in 
      exuberant VSN axonal projections and a delay in axonal coalescence into well 
      defined glomeruli in the AOB. Finally, we show that mitral cell dendritic 
      refinement occurs just after the coalescence of presynaptic axons. Such a 
      mechanism may allow the formation of precise connectivity with specific glomeruli 
      that receive input from sensory neurons expressing the same receptor type.
FAU - Hovis, Kenneth R
AU  - Hovis KR
AD  - Department of Biological Sciences, Center for the Neural Basis of Cognition, 
      Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, USA.
FAU - Ramnath, Rohit
AU  - Ramnath R
FAU - Dahlen, Jeffrey E
AU  - Dahlen JE
FAU - Romanova, Anna L
AU  - Romanova AL
FAU - LaRocca, Greg
AU  - LaRocca G
FAU - Bier, Mark E
AU  - Bier ME
FAU - Urban, Nathaniel N
AU  - Urban NN
LA  - eng
GR  - R21 DC006631/DC/NIDCD NIH HHS/United States
GR  - R21 DC006631-01/DC/NIDCD NIH HHS/United States
GR  - R01 DC005798-01/DC/NIDCD NIH HHS/United States
GR  - R01 DC005798/DC/NIDCD NIH HHS/United States
GR  - F31 DC009376-01/DC/NIDCD NIH HHS/United States
GR  - R01 DC011184/DC/NIDCD NIH HHS/United States
GR  - F31 DC009376/DC/NIDCD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
RN  - 0 (Neuropeptides)
RN  - 0 (Proto-Oncogene Proteins c-fos)
RN  - 0 (Receptors, Presynaptic)
SB  - IM
MH  - Animals
MH  - Axons/physiology
MH  - Dendrites/drug effects/physiology
MH  - Electroporation
MH  - Female
MH  - Freeze Drying
MH  - Gene Expression/drug effects/physiology
MH  - Genes, MHC Class I/genetics
MH  - Image Processing, Computer-Assisted
MH  - Immunohistochemistry
MH  - Male
MH  - Mice
MH  - Mice, Transgenic
MH  - Microscopy, Confocal
MH  - Neural Pathways/growth & development/*physiology
MH  - Neuropeptides/physiology/urine
MH  - Olfactory Bulb/growth & development/*physiology
MH  - Olfactory Receptor Neurons/physiology
MH  - Patch-Clamp Techniques
MH  - Proto-Oncogene Proteins c-fos/metabolism
MH  - Receptors, Presynaptic/physiology
MH  - Smell/*physiology
MH  - Vomeronasal Organ/growth & development/*innervation/physiology
PMC - PMC3483887
MID - NIHMS383641
EDAT- 2012/06/08 06:00
MHDA- 2012/08/10 06:00
PMCR- 2012/12/06
CRDT- 2012/06/08 06:00
PHST- 2012/06/08 06:00 [entrez]
PHST- 2012/06/08 06:00 [pubmed]
PHST- 2012/08/10 06:00 [medline]
PHST- 2012/12/06 00:00 [pmc-release]
AID - 32/23/7907 [pii]
AID - 3779289 [pii]
AID - 10.1523/JNEUROSCI.2399-11.2012 [doi]
PST - ppublish
SO  - J Neurosci. 2012 Jun 6;32(23):7907-16. doi: 10.1523/JNEUROSCI.2399-11.2012.