PMID- 22674568
OWN - NLM
STAT- MEDLINE
DCOM- 20130709
LR  - 20130102
IS  - 1099-1492 (Electronic)
IS  - 0952-3480 (Linking)
VI  - 26
IP  - 1
DP  - 2013 Jan
TI  - Structural and functional abnormalities in migraine patients without aura.
PG  - 58-64
LID - 10.1002/nbm.2819 [doi]
AB  - Migraine is a primary headache disorder characterized by recurrent attacks of 
      throbbing pain associated with neurological, gastrointestinal and autonomic 
      symptoms. Previous studies have detected structural deficits and functional 
      impairments in migraine patients. However, researchers have failed to investigate 
      the functional connectivity alterations of regions with structural deficits 
      during the resting state. Twenty-one migraine patients without aura and 21 age- 
      and gender-matched healthy controls participated in our study. Voxel-based 
      morphometric (VBM) analysis and functional connectivity were employed to 
      investigate the abnormal structural and resting-state properties, respectively, 
      in migraine patients without aura. Relative to healthy comparison subjects, 
      migraine patients showed significantly decreased gray matter volume in five brain 
      regions: the left medial prefrontal cortex (MPFC), dorsal anterior cingulate 
      cortex (dACC), right occipital lobe, cerebellum and brainstem. The gray matter 
      volume of the dACC was correlated with the duration of disease in migraine 
      patients, and thus we chose this region as the seeding area for resting-state 
      analysis. We found that migraine patients showed increased functional 
      connectivity between several regions and the left dACC, i.e. the bilateral middle 
      temporal lobe, orbitofrontal cortex (OFC) and left dorsolateral prefrontal cortex 
      (DLPFC). Furthermore, the functional connectivity between the dACC and two 
      regions (i.e. DLPFC and OFC) was correlated with the duration of disease in 
      migraine patients. We suggest that frequent nociceptive input has modified the 
      structural and functional patterns of the frontal cortex, and these changes may 
      explain the functional impairments in migraine patients.
CI  - Copyright (c) 2012 John Wiley & Sons, Ltd.
FAU - Jin, Chenwang
AU  - Jin C
AD  - Department of Medical Imaging, First Affiliated Hospital of Medical College, 
      Xi'an Jiaotong University, Xi'an, China.
FAU - Yuan, Kai
AU  - Yuan K
FAU - Zhao, Limei
AU  - Zhao L
FAU - Zhao, Ling
AU  - Zhao L
FAU - Yu, Dahua
AU  - Yu D
FAU - von Deneen, Karen M
AU  - von Deneen KM
FAU - Zhang, Ming
AU  - Zhang M
FAU - Qin, Wei
AU  - Qin W
FAU - Sun, Weixin
AU  - Sun W
FAU - Tian, Jie
AU  - Tian J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120607
PL  - England
TA  - NMR Biomed
JT  - NMR in biomedicine
JID - 8915233
SB  - IM
MH  - Adult
MH  - Aged
MH  - Brain/*pathology/*physiopathology
MH  - Brain Mapping/methods
MH  - Connectome/methods
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - Migraine without Aura/*pathology/*physiopathology
MH  - Nerve Net/*pathology/*physiopathology
EDAT- 2012/06/08 06:00
MHDA- 2013/07/10 06:00
CRDT- 2012/06/08 06:00
PHST- 2011/09/20 00:00 [received]
PHST- 2012/04/14 00:00 [revised]
PHST- 2012/04/18 00:00 [accepted]
PHST- 2012/06/08 06:00 [entrez]
PHST- 2012/06/08 06:00 [pubmed]
PHST- 2013/07/10 06:00 [medline]
AID - 10.1002/nbm.2819 [doi]
PST - ppublish
SO  - NMR Biomed. 2013 Jan;26(1):58-64. doi: 10.1002/nbm.2819. Epub 2012 Jun 7.