PMID- 2267476
OWN - NLM
STAT- MEDLINE
DCOM- 19910208
LR  - 20190510
IS  - 0161-8105 (Print)
IS  - 0161-8105 (Linking)
VI  - 13
IP  - 4
DP  - 1990 Aug
TI  - DR2-positive monozygotic twins discordant for narcolepsy.
PG  - 336-43
AB  - Narcolepsy runs in families, and recent research has revealed the human leukocyte 
      antigen (HLA) DR2 to be a genetic marker closely associated with the disease. 
      But, as indicated by family studies, other factors contribute to the pathogenesis 
      of narcolepsy. The investigation of monozygotic twins is the most specific 
      research tool for distinguishing between a multigenetic and a multifactorial 
      pathogenetic model. We present clinical and sleep polygraphic data from two pairs 
      of monozygotic twins, and in addition, from some of their first-degree relatives. 
      In both pairs only one twin suffered from the clinical symptoms of 
      narcolepsy/cataplexy. Only in these subjects did night sleep recordings and a 
      multiple sleep latency test reveal both multiple sleep onset rapid-eye-movement 
      periods (SOREMPs) and short mean sleep onset latencies. However, in two of the 
      asymptomatic, HLA DR2+ relatives, short mean sleep onset latencies during the 
      multiple sleep latency test (MSLT) were observed, and one, HLA DR2- relative 
      showed REM sleep two times during the MSLT. Our results strongly favor a 
      multifactorial pathogenetic model for narcolepsy.
FAU - Pollmacher, T
AU  - Pollmacher T
AD  - Max Planck Institute for Psychiatry, Munich, F.R.G.
FAU - Schulz, H
AU  - Schulz H
FAU - Geisler, P
AU  - Geisler P
FAU - Kiss, E
AU  - Kiss E
FAU - Albert, E D
AU  - Albert ED
FAU - Schwarzfischer, F
AU  - Schwarzfischer F
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Sleep
JT  - Sleep
JID - 7809084
RN  - 0 (HLA-DR2 Antigen)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Diseases in Twins/diagnosis/*genetics
MH  - Electroencephalography
MH  - Female
MH  - HLA-DR2 Antigen/*genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Narcolepsy/diagnosis/*genetics
MH  - Pedigree
MH  - Reaction Time/genetics
MH  - Sleep Stages/genetics
MH  - Sleep, REM/genetics
EDAT- 1990/08/01 00:00
MHDA- 1990/08/01 00:01
CRDT- 1990/08/01 00:00
PHST- 1990/08/01 00:00 [pubmed]
PHST- 1990/08/01 00:01 [medline]
PHST- 1990/08/01 00:00 [entrez]
AID - 10.1093/sleep/13.4.336 [doi]
PST - ppublish
SO  - Sleep. 1990 Aug;13(4):336-43. doi: 10.1093/sleep/13.4.336.