PMID- 22676318
OWN - NLM
STAT- MEDLINE
DCOM- 20130916
LR  - 20220330
IS  - 1525-6006 (Electronic)
IS  - 1064-1963 (Linking)
VI  - 35
IP  - 2
DP  - 2013
TI  - Cardiac autonomic function measured by heart rate variability and turbulence in 
      pre-hypertensive subjects.
PG  - 102-7
LID - 10.3109/10641963.2012.690475 [doi]
AB  - Non-dipping blood pressure pattern was shown to be associated with increased 
      cardiovascular events. In addition, cardiac autonomic dysfunction was found to be 
      associated with non-dipper phenomenon. In this study, we aimed to evaluate the 
      cardiac autonomic functions in dipper and non-dipper pre-hypertensive subjects. A 
      total of 65 pre-hypertensive subjects were enrolled in this study. They were 
      divided into two groups as non-dippers (40 subjects, 52% female) and dippers (25 
      subjects, 52.5% female). Cardiac autonomic functions of the two groups were 
      compared with the aid of heart rate variability, heart rate turbulence (HRT), 
      atrial premature contractions (APCs), ventricular premature contractions (VPCs), 
      and mean heart rate (MHR). There was no significant difference between 
      non-dippers and dippers in basal characteristics. The two parameters of HRT, 
      turbulence onset and turbulence slope, were found to be significantly abnormal in 
      non-dippers than in dippers (P < .011 and P < .002, respectively). Heart rate 
      variability parameters, including SDNN, SDANN, RMSSD, and pNN50, were found to be 
      similar in dipper and non-dipper pre-hypertensive subjects (P < .998, P < .453, P 
      < .205, and P < .788, respectively). APCs, VPCs, and MHR were compared, and there 
      were statistical differences between the groups (APCs 5.80 +/- 4.55, 9.14 +/- 7.33, P 
      < .024; VPCs 8.48 +/- 8.83, 13.23 +/- 9.68, P < .044; and MHR 70.16 +/- 11.08, 76.26 +/- 
      11.31, P < .035; respectively). This study demonstrated a possible cardiac 
      autonomic dysfunction in pre-hypertensive subjects with non-dipper pattern. This 
      may be a basis for future studies related to pre-hypertension and non-dipping BP 
      pattern.
FAU - Erdem, Alim
AU  - Erdem A
AD  - Department of Cardiology, Medical Faculty, Abant Izzet Baysal University, Bolu, 
      Turkey. cardiology14@gmail.com
FAU - Uenishi, Masahiro
AU  - Uenishi M
FAU - Kucukdurmaz, Zekeriya
AU  - Kucukdurmaz Z
FAU - Matsumoto, Kazuo
AU  - Matsumoto K
FAU - Kato, Ritsushi
AU  - Kato R
FAU - Hara, Motoki
AU  - Hara M
FAU - Yazici, Mehmet
AU  - Yazici M
LA  - eng
PT  - Journal Article
DEP - 20120607
PL  - England
TA  - Clin Exp Hypertens
JT  - Clinical and experimental hypertension (New York, N.Y. : 1993)
JID - 9305929
SB  - IM
MH  - Adult
MH  - Autonomic Nervous System/*physiology
MH  - Blood Pressure/physiology
MH  - Blood Pressure Monitoring, Ambulatory
MH  - Circadian Rhythm/physiology
MH  - Female
MH  - Heart/*physiology
MH  - Heart Rate/*physiology
MH  - Humans
MH  - Hypertension/physiopathology
MH  - Male
MH  - Middle Aged
MH  - Prehypertension/*physiopathology
EDAT- 2012/06/09 06:00
MHDA- 2013/09/17 06:00
CRDT- 2012/06/09 06:00
PHST- 2012/06/09 06:00 [entrez]
PHST- 2012/06/09 06:00 [pubmed]
PHST- 2013/09/17 06:00 [medline]
AID - 10.3109/10641963.2012.690475 [doi]
PST - ppublish
SO  - Clin Exp Hypertens. 2013;35(2):102-7. doi: 10.3109/10641963.2012.690475. Epub 
      2012 Jun 7.