PMID- 22676477
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121203
LR  - 20211021
IS  - 1710-1492 (Electronic)
IS  - 1710-1484 (Print)
IS  - 1710-1484 (Linking)
VI  - 8
IP  - 1
DP  - 2012 Jun 7
TI  - Predictive value of IgE/IgG4 antibody ratio in children with egg allergy.
PG  - 9
LID - 10.1186/1710-1492-8-9 [doi]
AB  - BACKGROUND: The aim of this study was to investigate the role of specific IgG4 
      antibodies to hen's egg white and determine their utility as a marker for the 
      outcome of oral challenge test in children sensitized to hen's egg METHODS: The 
      hen's egg oral food challenge test was performed in 105 sensitized children 
      without atopic dermatitis, and the titers of egg white-specific immunoglobulin G4 
      (IgG4) and immunoglobulin E (IgE) antibodies were measured. To set the cut-off 
      values of IgG4, IgE, and the IgE/IgG4 ratio for predicting positive results in 
      oral challenges, receiver operating characteristic curves were plotted and the 
      area under the curves (AUC) were calculated. RESULTS: Sixty-four of 105 oral 
      challenges with whole eggs were assessed as positive. The AUC for IgE, IgG4, and 
      IgE/IgG4 for the prediction of positive results were 0.609, 0.724, and 0.847, 
      respectively. Thus, the IgE/IgG4 ratio generated significantly higher 
      specificity, sensitivity, positive predictive value (%), and negative predictive 
      value (%) than the individual IgE and IgG4. The negative predictive value of the 
      IgE/IgG4 ratio was 90% at a value of 1. CONCLUSIONS: We have demonstrated that 
      the egg white-specific serum IgE/IgG4 ratio is important for predicting 
      reactivity to egg during food challenges.
FAU - Okamoto, Shindou
AU  - Okamoto S
AD  - Department of Pediatrics, Kansai Medical University, Fumizonocho 10-15, 
      Moriguchi, Osaka, 570-8506, Japan. taniuchi@takii.kmu.ac.jp.
FAU - Taniuchi, Shoichiro
AU  - Taniuchi S
FAU - Sudo, Kyoko
AU  - Sudo K
FAU - Hatano, Yasuko
AU  - Hatano Y
FAU - Nakano, Keiji
AU  - Nakano K
FAU - Shimo, Tomohiko
AU  - Shimo T
FAU - Kaneko, Kazunari
AU  - Kaneko K
LA  - eng
PT  - Journal Article
DEP - 20120607
PL  - England
TA  - Allergy Asthma Clin Immunol
JT  - Allergy, asthma, and clinical immunology : official journal of the Canadian 
      Society of Allergy and Clinical Immunology
JID - 101244313
EIN - Allergy Asthma Clin Immunol. 2013 Sep 09;9(1):34. PMID: 24015800
PMC - PMC3511811
EDAT- 2012/06/09 06:00
MHDA- 2012/06/09 06:01
PMCR- 2012/06/07
CRDT- 2012/06/09 06:00
PHST- 2012/01/04 00:00 [received]
PHST- 2012/05/18 00:00 [accepted]
PHST- 2012/06/09 06:00 [entrez]
PHST- 2012/06/09 06:00 [pubmed]
PHST- 2012/06/09 06:01 [medline]
PHST- 2012/06/07 00:00 [pmc-release]
AID - 1710-1492-8-9 [pii]
AID - 10.1186/1710-1492-8-9 [doi]
PST - epublish
SO  - Allergy Asthma Clin Immunol. 2012 Jun 7;8(1):9. doi: 10.1186/1710-1492-8-9.