PMID- 22676973
OWN - NLM
STAT- MEDLINE
DCOM- 20120806
LR  - 20161125
IS  - 1096-0333 (Electronic)
IS  - 0041-008X (Linking)
VI  - 262
IP  - 1
DP  - 2012 Jul 1
TI  - Acute alteration of cardiac ECG, action potential, I(Kr) and the human 
      ether-a-go-go-related gene (hERG) K+ channel by PCB 126 and PCB 77.
PG  - 60-9
LID - 10.1016/j.taap.2012.04.019 [doi]
AB  - Polychlorinated biphenyls (PCBs) have been known as serious persistent organic 
      pollutants (POPs), causing developmental delays and motor dysfunction. We have 
      investigated the effects of two PCB congeners, 3,3',4,4'-tetrachlorobiphenyl (PCB 
      77) and 3,3',4,4',5-pentachlorobiphenyl (PCB 126) on ECG, action potential, and 
      the rapidly activating delayed rectifier K+ current (I(Kr)) of guinea pigs' 
      hearts, and hERG K+ current expressed in Xenopus oocytes. PCB 126 shortened the 
      corrected QT interval (QTc) of ECG and decreased the action potential duration at 
      90% (APD(90)), and 50% of repolarization (APD(5)(0)) (P<0.05) without changing the 
      action potential duration at 20% (APD(2)(0)). PCB 77 decreased APD(2)(0) (P<0.05) without 
      affecting QTc, APD(9)(0), and APD(5)(0). The PCB 126 increased the I(Kr) in guinea-pig 
      ventricular myocytes held at 36 degrees C and hERG K+ current amplitude at the end of the 
      voltage steps in voltage-dependent mode (P<0.05); however, PCB 77 did not change 
      the hERG K+ current amplitude. The PCB 77 increased the diastolic Ca(2)(+) and 
      decreased Ca(2)(+) transient amplitude (P<0.05), however PCB 126 did not change. The 
      results suggest that PCB 126 shortened the QTc and decreased the APD(9)(0) possibly 
      by increasing I(Kr), while PCB 77 decreased the APD(2)(0) possibly by other 
      modulation related with intracellular Ca(2)(+). The present data indicate that the 
      environmental toxicants, PCBs, can acutely affect cardiac electrophysiology 
      including ECG, action potential, intracellular Ca(2)(+), and channel activity, 
      resulting in toxic effects on the cardiac function in view of the possible 
      accumulation of the PCBs in human body.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Park, Mi-Hyeong
AU  - Park MH
AD  - Department of Physiology, Institute of Bioscience and Biotechnology, Kangwon 
      National University College of Medicine, Chuncheon 200-701, Republic of Korea.
FAU - Park, Won Sun
AU  - Park WS
FAU - Jo, Su-Hyun
AU  - Jo SH
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120428
PL  - United States
TA  - Toxicol Appl Pharmacol
JT  - Toxicology and applied pharmacology
JID - 0416575
RN  - 0 (Delayed Rectifier Potassium Channels)
RN  - 0 (ERG1 Potassium Channel)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Ether-A-Go-Go Potassium Channels)
RN  - 0 (KCNH2 protein, human)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
RN  - SY7Q814VUP (Calcium)
RN  - TSH69IA9XF (3,4,5,3',4'-pentachlorobiphenyl)
RN  - Y2I6546TMI (3,4,3',4'-tetrachlorobiphenyl)
SB  - IM
MH  - Action Potentials/*drug effects
MH  - Animals
MH  - Calcium/metabolism
MH  - Delayed Rectifier Potassium Channels/*drug effects/metabolism
MH  - ERG1 Potassium Channel
MH  - Electrocardiography
MH  - Environmental Pollutants/toxicity
MH  - Ether-A-Go-Go Potassium Channels/*drug effects/metabolism
MH  - Guinea Pigs
MH  - Heart Ventricles/cytology/drug effects/metabolism
MH  - Humans
MH  - Myocytes, Cardiac/drug effects/metabolism
MH  - Oocytes
MH  - Polychlorinated Biphenyls/*toxicity
MH  - Xenopus laevis
EDAT- 2012/06/09 06:00
MHDA- 2012/08/07 06:00
CRDT- 2012/06/09 06:00
PHST- 2012/03/05 00:00 [received]
PHST- 2012/04/16 00:00 [revised]
PHST- 2012/04/17 00:00 [accepted]
PHST- 2012/06/09 06:00 [entrez]
PHST- 2012/06/09 06:00 [pubmed]
PHST- 2012/08/07 06:00 [medline]
AID - S0041-008X(12)00155-X [pii]
AID - 10.1016/j.taap.2012.04.019 [doi]
PST - ppublish
SO  - Toxicol Appl Pharmacol. 2012 Jul 1;262(1):60-9. doi: 10.1016/j.taap.2012.04.019. 
      Epub 2012 Apr 28.