PMID- 22677226
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 1873-2747 (Electronic)
IS  - 0361-9230 (Linking)
VI  - 88
IP  - 5
DP  - 2012 Aug 1
TI  - Reprint of: Effects of BDNF polymorphisms on brain function and behavior in 
      health and disease.
PG  - 406-17
AB  - Brain-derived neurotrophic factor (BDNF), the most abundant neurotrophin in the 
      brain, serves an important role during brain development and in synaptic 
      plasticity. Given its pleiotropic effects in the central nervous system, BDNF has 
      been implicated in cognitive function and personality development as well as the 
      pathogenesis of various psychiatric disorders. Thus, BDNF is considered an 
      attractive candidate gene for the study of healthy and diseased brain function 
      and behaviors. Over the past decade, many studies have tested BDNF genetic 
      association, particularly its functional Val66Met polymorphism, with psychiatric 
      diseases, personality disorders, and cognitive function. Although many reports 
      indicated a possible role for BDNF genetic effects in mental problems or brain 
      function, other reports were unable to replicate the findings. The conflicting 
      results in BDNF genetic studies may result from confounding factors such as age, 
      gender, other environmental factors, sample size, ethnicity and phenotype 
      assessment. Future studies with more homogenous populations, well-controlled 
      confounding factors, and well-defined phenotypes are needed to clarify the BDNF 
      genetic effects on mental diseases and human behaviors.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Hong, Chen-Jee
AU  - Hong CJ
AD  - Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan.
FAU - Liou, Ying-Jay
AU  - Liou YJ
FAU - Tsai, Shih-Jen
AU  - Tsai SJ
LA  - eng
PT  - Journal Article
DEP - 20120604
PL  - United States
TA  - Brain Res Bull
JT  - Brain research bulletin
JID - 7605818
SB  - IM
RPF - Brain Res Bull. 2011 Nov 25;86(5-6):287-97. PMID: 21924328
EDAT- 2012/06/09 06:00
MHDA- 2012/06/09 06:01
CRDT- 2012/06/09 06:00
PHST- 2011/06/13 00:00 [received]
PHST- 2011/08/22 00:00 [revised]
PHST- 2011/08/31 00:00 [accepted]
PHST- 2012/06/09 06:00 [entrez]
PHST- 2012/06/09 06:00 [pubmed]
PHST- 2012/06/09 06:01 [medline]
AID - S0361-9230(12)00124-4 [pii]
AID - 10.1016/j.brainresbull.2012.05.016 [doi]
PST - ppublish
SO  - Brain Res Bull. 2012 Aug 1;88(5):406-17. doi: 10.1016/j.brainresbull.2012.05.016. 
      Epub 2012 Jun 4.