PMID- 22677942
OWN - NLM
STAT- MEDLINE
DCOM- 20121112
LR  - 20211021
IS  - 1559-2308 (Electronic)
IS  - 1559-2294 (Print)
IS  - 1559-2294 (Linking)
VI  - 7
IP  - 7
DP  - 2012 Jul
TI  - SIRT1-mediated deacetylation of MeCP2 contributes to BDNF expression.
PG  - 695-700
LID - 10.4161/epi.20733 [doi]
AB  - Methyl-CpG binding protein 2 (MeCP2) binds methylated cytosines at CpG sites on 
      DNA and it is thought to function as a critical epigenetic regulator. Mutations 
      in the MeCP2 gene have been associated to Rett syndrome, a human 
      neurodevelopmental disorder. Here we show that MeCP2 is acetylated by p300 and 
      that SIRT1 mediates its deacetylation. SIRT1, the mammalian homologue of Sir2 in 
      yeast, is a nicotinamide-adenine dinucleotide (NAD(+))-dependent histone 
      deacetylase that belongs to the family of HDAC class III sirtuins. Importantly, 
      SIRT1 has been shown to play a critical role in synaptic plasticity and memory 
      formation. This study reveals a functional interplay between two critical 
      epigenetic regulators, MeCP2 and SIRT1, which controls MeCP2 binding activity to 
      the brain-derived neurotrophic factor (BDNF) promoter in a specific region of the 
      brain.
FAU - Zocchi, Loredana
AU  - Zocchi L
AD  - Center for Epigenetics and Metabolism, School of Medicine, University of 
      California at Irvine, Irvine, CA, USA.
FAU - Sassone-Corsi, Paolo
AU  - Sassone-Corsi P
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20120701
PL  - United States
TA  - Epigenetics
JT  - Epigenetics
JID - 101265293
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Mecp2 protein, mouse)
RN  - 0 (Methyl-CpG-Binding Protein 2)
RN  - EC 2.3.1.48 (p300-CBP Transcription Factors)
RN  - EC 3.5.1.- (Sirt1 protein, mouse)
RN  - EC 3.5.1.- (Sirtuin 1)
RN  - K3Z4F929H6 (Lysine)
SB  - IM
MH  - Acetylation
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Lysine/metabolism
MH  - Methyl-CpG-Binding Protein 2/genetics/*metabolism
MH  - Mice
MH  - Mice, Mutant Strains
MH  - Mutation
MH  - Neurons/metabolism
MH  - Sirtuin 1/genetics/*metabolism
MH  - p300-CBP Transcription Factors/metabolism
PMC - PMC3414390
EDAT- 2012/06/09 06:00
MHDA- 2012/11/13 06:00
PMCR- 2012/07/01
CRDT- 2012/06/09 06:00
PHST- 2012/06/09 06:00 [entrez]
PHST- 2012/06/09 06:00 [pubmed]
PHST- 2012/11/13 06:00 [medline]
PHST- 2012/07/01 00:00 [pmc-release]
AID - 20733 [pii]
AID - 2012EPI0140R [pii]
AID - 10.4161/epi.20733 [doi]
PST - ppublish
SO  - Epigenetics. 2012 Jul;7(7):695-700. doi: 10.4161/epi.20733. Epub 2012 Jul 1.