PMID- 22678564
OWN - NLM
STAT- MEDLINE
DCOM- 20121128
LR  - 20231213
IS  - 1651-2057 (Electronic)
IS  - 0001-5555 (Linking)
VI  - 92
IP  - 3
DP  - 2012 May
TI  - Distribution and maturation of skin dendritic cell subsets in two forms of 
      cutaneous T-cell lymphoma: mycosis fungoides and Sezary syndrome.
PG  - 269-75
LID - 10.2340/00015555-1220 [doi]
AB  - Dendritic cells (DCs) critically regulate immune responses and the 
      "immune-surveillance" of tumours. This study retrospectively analysed the 
      distribution and maturation status of DC-subsets in T-cell lymphoma of the skin. 
      Mycosis fungoides and Sezary syndrome (n = 25) were investigated 
      immunohistochemically for DC subsets, based on C-type lectin receptor expression: 
      Langerhans' cells (langerin/CD207+, DEC-205/CD205+), dermal DCs (DC-SIGN/CD209+, 
      CD205+) and plasmacytoid DC (BDCA-2/CD303+). Maturation status was assessed by 
      double-labelling for CD83 and CD208/DC-LAMP. DCs were interspersed between the 
      neoplastic infiltrate, and a marked increase in numbers of all three subsets was 
      noted, DC-SIGN+ dermal DCs constituting the majority. Substantial numbers of 
      plasmacytoid DCs were consistently observed. Most DCs in epidermis and dermis 
      were phenotypically immature. Amongst the relatively few mature DCs in the 
      dermis, langerin+ cells predominated. There was a positive correlation between 
      the histological intensity of the tumour infiltrate and DC numbers. It is 
      possible that mature DCs reflect ongoing anti-tumour immune responses, and 
      immature DCs the induction of tumour tolerance.
FAU - Schwingshackl, Philipp
AU  - Schwingshackl P
AD  - Department of Dermatology & Venereology, Innsbruck Medical University, Innsbruck, 
      Austria.
FAU - Obermoser, Gerlinde
AU  - Obermoser G
FAU - Nguyen, Van Anh
AU  - Nguyen VA
FAU - Fritsch, Peter
AU  - Fritsch P
FAU - Sepp, Norbert
AU  - Sepp N
FAU - Romani, Nikolaus
AU  - Romani N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Sweden
TA  - Acta Derm Venereol
JT  - Acta dermato-venereologica
JID - 0370310
RN  - 0 (Antigens, CD)
RN  - 0 (CLEC4C protein, human)
RN  - 0 (Cell Adhesion Molecules)
RN  - 0 (DC-specific ICAM-3 grabbing nonintegrin)
RN  - 0 (DEC-205 receptor)
RN  - 0 (Immunoglobulins)
RN  - 0 (Lectins, C-Type)
RN  - 0 (Lysosomal-Associated Membrane Protein 3)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Minor Histocompatibility Antigens)
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (Receptors, Immunologic)
SB  - IM
MH  - Antigens, CD/metabolism
MH  - Cell Adhesion Molecules/metabolism
MH  - Dendritic Cells/*metabolism/*pathology
MH  - Humans
MH  - Immunoglobulins/metabolism
MH  - Langerhans Cells/metabolism/pathology
MH  - Lectins, C-Type/metabolism
MH  - Lysosomal-Associated Membrane Protein 3/metabolism
MH  - Membrane Glycoproteins/metabolism
MH  - Minor Histocompatibility Antigens
MH  - Mycosis Fungoides/*pathology
MH  - Receptors, Cell Surface/metabolism
MH  - Receptors, Immunologic/metabolism
MH  - Retrospective Studies
MH  - Sezary Syndrome/*pathology
MH  - Skin Neoplasms/*pathology
MH  - CD83 Antigen
EDAT- 2012/06/09 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/06/09 06:00
PHST- 2012/06/09 06:00 [entrez]
PHST- 2012/06/09 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - 10.2340/00015555-1220 [doi]
PST - ppublish
SO  - Acta Derm Venereol. 2012 May;92(3):269-75. doi: 10.2340/00015555-1220.