PMID- 22678895
OWN - NLM
STAT- MEDLINE
DCOM- 20120813
LR  - 20120608
IS  - 1521-4141 (Electronic)
IS  - 0014-2980 (Linking)
VI  - 42
IP  - 6
DP  - 2012 Jun
TI  - Naturally occurring CD1c+ human regulatory dendritic cells: immunoregulators that 
      are expanded in response to E. coli infection.
PG  - 1388-92
LID - 10.1002/eji.201242632 [doi]
AB  - Dendritic cells (DCs) play key roles in initiating and regulating immunity by 
      sensing and integrating signals from a wide range of pathogens and dangers. 
      Although much knowledge has been gained about the origins, phenotypes, and 
      functions of mouse DC subsets, the challenge now is to translate this knowledge 
      to the human immune system and reveal relevant biological significance in human 
      health and disease. Considerably less is known about the phenotype and function 
      of human DC subsets due to their rarity, the lack of distinctive markers, and 
      limited access to human tissues. Initial studies of DCs in human blood revealed 
      that steady-state myeloid DCs are comprised of the CD141(+) and CD1c(+) DC 
      subsets as the equivalents to the mouse lymphoid resident CD8(+) and CD8(-) DC 
      subsets, respectively. A new report in this issue of the European Journal of 
      Immunology [Eur. J. Immunol. 2012. 42: 1512-1522] shows that human CD1c(+) 
      myeloid DCs secrete IL-10 and display an immunoregulatory phenotype and function 
      in response to Escherichia coli (E. coli). This finding adds a new element to the 
      current understanding of human CD1c(+) DCs and reveals marked differences in 
      human DC subsets during inflammation and microbial infection, as discussed in 
      this Commentary.
CI  - (c) 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
FAU - Qian, Cheng
AU  - Qian C
AD  - National Key Laboratory of Medical Immunology & Institute of Immunology, Second 
      Military Medical University, Shanghai, China. crystalqiancheng@yahoo.com.cn
FAU - Cao, Xuetao
AU  - Cao X
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Eur J Immunol
JT  - European journal of immunology
JID - 1273201
RN  - 0 (Antigens, CD)
RN  - 0 (Antigens, CD1)
RN  - 0 (CD1C protein, human)
RN  - 0 (Glycoproteins)
RN  - 0 (Integrin alpha Chains)
RN  - 0 (Toll-Like Receptors)
RN  - 0 (alpha E integrins)
RN  - 130068-27-8 (Interleukin-10)
SB  - IM
MH  - Animals
MH  - Antigens, CD/analysis
MH  - Antigens, CD1/*analysis
MH  - Dendritic Cells/*immunology
MH  - Escherichia coli Infections/*immunology
MH  - Glycoproteins/*analysis
MH  - Humans
MH  - Integrin alpha Chains/analysis
MH  - Interleukin-10/physiology
MH  - Mice
MH  - Toll-Like Receptors/physiology
EDAT- 2012/06/09 06:00
MHDA- 2012/08/14 06:00
CRDT- 2012/06/09 06:00
PHST- 2012/06/09 06:00 [entrez]
PHST- 2012/06/09 06:00 [pubmed]
PHST- 2012/08/14 06:00 [medline]
AID - 10.1002/eji.201242632 [doi]
PST - ppublish
SO  - Eur J Immunol. 2012 Jun;42(6):1388-92. doi: 10.1002/eji.201242632.