PMID- 22679420 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20121002 LR - 20211021 IS - 1662-5129 (Electronic) IS - 1662-5129 (Linking) VI - 6 DP - 2012 TI - Contribution of pheromones processed by the main olfactory system to mate recognition in female mammals. PG - 20 LID - 10.3389/fnana.2012.00020 [doi] LID - 20 AB - Until recently it was widely believed that the ability of female mammals (with the likely exception of women) to identify and seek out a male breeding partner relied on the detection of non-volatile male pheromones by the female's vomeronasal organ (VNO) and their subsequent processing by a neural circuit that includes the accessory olfactory bulb (AOB), vomeronasal amygdala, and hypothalamus. Emperical data are reviewed in this paper that demonstrate the detection of volatile pheromones by the main olfactory epithelium (MOE) of female mice which, in turn, leads to the activation of a population of glomeruli and abutting mitral cells in the main olfactory bulb (MOB). Anatomical results along with functional neuroanatomical data demonstrate that some of these MOB mitral cells project to the vomeronasal amygdala. These particular MOB mitral cells were selectively activated (i.e., expressed Fos protein) by exposure to male as opposed to female urinary volatiles. A similar selectivity to opposite sex urinary volatiles was also seen in mitral cells of the AOB of female mice. Behavioral data from female mouse, ferret, and human are reviewed that implicate the main olfactory system, in some cases interacting with the accessory olfactory system, in mate recognition. FAU - Baum, Michael J AU - Baum MJ AD - Department of Biology, Boston University, Boston MA, USA. LA - eng PT - Journal Article DEP - 20120605 PL - Switzerland TA - Front Neuroanat JT - Frontiers in neuroanatomy JID - 101477943 PMC - PMC3367429 OTO - NOTNLM OT - ferret OT - human OT - hypothalamus OT - mouse OT - vomeronasal organ EDAT- 2012/06/09 06:00 MHDA- 2012/06/09 06:01 PMCR- 2012/01/01 CRDT- 2012/06/09 06:00 PHST- 2012/04/17 00:00 [received] PHST- 2012/05/19 00:00 [accepted] PHST- 2012/06/09 06:00 [entrez] PHST- 2012/06/09 06:00 [pubmed] PHST- 2012/06/09 06:01 [medline] PHST- 2012/01/01 00:00 [pmc-release] AID - 10.3389/fnana.2012.00020 [doi] PST - epublish SO - Front Neuroanat. 2012 Jun 5;6:20. doi: 10.3389/fnana.2012.00020. eCollection 2012.