PMID- 22679827
OWN - NLM
STAT- MEDLINE
DCOM- 20130712
LR  - 20190923
IS  - 1000-8713 (Print)
IS  - 1000-8713 (Linking)
VI  - 30
IP  - 2
DP  - 2012 Feb
TI  - [A novel solid phase extraction column combined with ultra performance liquid 
      chromatography/tandem mass spectrometry for selective enrichment and 
      determination of clenbuterol in pork].
PG  - 141-5
AB  - A simple and efficient method based on a novel solid phase extraction (SPE) 
      cartridge and ultra performance liquid chromatography-tandem mass spectrometry 
      (UPLC-MS/ MS) was developed for the determination of clenbuterol residue in pork. 
      The minced pork sample was ultrasonically extracted by 5% (v/v) perchloric acid 
      and centrifuged at 10 000 r/min for 15 min, then the supernatant was purified by 
      an SMCX cartridge, which is a novel SPE column based on homemade silica matrix 
      with two mixed modes of reversed-phase and strong cation exchange, for the 
      selective enrichment and purification of the analyte. The linear range of the 
      method was 0.25 - 50 microg/kg with a correlation coefficient of 0.998 2. The 
      average recoveries ranged from 62.2% to 72.0% at the three spiked levels of 1.25, 
      12.5 and 50 microg/kg with the relative standard deviations (RSDs) between 4.2% 
      and 6.1%. The limit of detection (S/N = 3) was 0.05 microg/kg. The method is 
      simple, fast and can be extended to enrich and determine beta-agonist drugs.
FAU - Meng, Wenying
AU  - Meng W
AD  - School of Pharmacy, East China University of Science and Technology, Shanghai 
      200237, China.
FAU - Guo, Zhimou
AU  - Guo Z
FAU - Shen, Weijian
AU  - Shen W
FAU - Shen, Chongyu
AU  - Shen C
FAU - Wu, Bin
AU  - Wu B
FAU - Liu, Yanming
AU  - Liu Y
FAU - Zhang, Feifang
AU  - Zhang F
FAU - Liang, Xinmiao
AU  - Liang X
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Se Pu
JT  - Se pu = Chinese journal of chromatography
JID - 9424804
RN  - 0 (Adrenergic beta-Agonists)
RN  - XTZ6AXU7KN (Clenbuterol)
SB  - IM
MH  - Adrenergic beta-Agonists/analysis
MH  - Animals
MH  - Chromatography, High Pressure Liquid/*methods
MH  - Clenbuterol/*analysis
MH  - Food Contamination/*analysis
MH  - Meat/*analysis
MH  - Solid Phase Extraction/methods
MH  - Swine
MH  - Tandem Mass Spectrometry/*methods
EDAT- 2012/06/12 06:00
MHDA- 2013/07/16 06:00
CRDT- 2012/06/12 06:00
PHST- 2012/06/12 06:00 [entrez]
PHST- 2012/06/12 06:00 [pubmed]
PHST- 2013/07/16 06:00 [medline]
AID - 10.3724/sp.j.1123.2011.09038 [doi]
PST - ppublish
SO  - Se Pu. 2012 Feb;30(2):141-5. doi: 10.3724/sp.j.1123.2011.09038.