PMID- 22681170
OWN - NLM
STAT- MEDLINE
DCOM- 20130531
LR  - 20190728
IS  - 1873-4286 (Electronic)
IS  - 1381-6128 (Linking)
VI  - 18
IP  - 36
DP  - 2012
TI  - Inflammatory cytokines, growth factors, and depression.
PG  - 5920-35
AB  - There is a plausible role for cytokines, brain-derived neurotrophic factor 
      (BDNF), and their interaction in major depressive disorder's (MDD) etiology. This 
      review includes (i) briefly defining cytokines, (ii) a discussion of theories for 
      why they may affect brain function, (iii) cross-sectional associations between 
      cytokines and MDD, (iv) the effect of antidepressants on cytokines, (v) the 
      behavioral effects of cytokines administration to humans, (vi) the behavior 
      effects of their administration to animal models, and (vii) potential 
      neurochemical systems influenced by cytokines. The role of BDNF is then briefly 
      examined, along with a review of several studies that have examined a Val/Met 
      polymorphism in the BDNF gene. The bidirectional relationship between BDNF and 
      cytokines is subsequently discussed. Potential ramifications for MDD treatment 
      that are appraised include (i) use of cytokine biomarkers for identifying 
      specific populations for targeted MDD therapy, (ii) the use of medications that 
      directly antagonize the role of inflammatory cytokines, (iii) potential indirect 
      modifiers of cytokine activity, and (iv) possible downstream intracellular second 
      messenger targets.
FAU - Lotrich, Francis
AU  - Lotrich F
AD  - Western Psychiatric Institute and Clinics, Pittsburgh, PA 15213, USA. 
      lotrichfe@upmc.edu
LA  - eng
GR  - MH090250/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
PL  - United Arab Emirates
TA  - Curr Pharm Des
JT  - Current pharmaceutical design
JID - 9602487
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Antidepressive Agents)
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Cytokines)
RN  - 0 (Inflammation Mediators)
SB  - IM
MH  - Animals
MH  - Anti-Inflammatory Agents/chemistry/therapeutic use
MH  - Antidepressive Agents/chemistry/therapeutic use
MH  - Biomarkers/metabolism
MH  - Brain/drug effects/immunology/*metabolism
MH  - Brain-Derived Neurotrophic Factor/genetics/*metabolism
MH  - Cytokines/antagonists & inhibitors/*metabolism
MH  - Depressive Disorder, Major/drug 
      therapy/genetics/immunology/*metabolism/psychology
MH  - Drug Design
MH  - Humans
MH  - Inflammation Mediators/antagonists & inhibitors/*metabolism
MH  - Polymorphism, Genetic
MH  - Signal Transduction/drug effects
EDAT- 2012/06/12 06:00
MHDA- 2013/06/01 06:00
CRDT- 2012/06/12 06:00
PHST- 2012/05/02 00:00 [received]
PHST- 2012/05/16 00:00 [accepted]
PHST- 2012/06/12 06:00 [entrez]
PHST- 2012/06/12 06:00 [pubmed]
PHST- 2013/06/01 06:00 [medline]
AID - CPD-EPUB-20120606-11 [pii]
AID - 10.2174/138161212803523680 [doi]
PST - ppublish
SO  - Curr Pharm Des. 2012;18(36):5920-35. doi: 10.2174/138161212803523680.