PMID- 22681243
OWN - NLM
STAT- MEDLINE
DCOM- 20121119
LR  - 20220317
IS  - 1520-5851 (Electronic)
IS  - 0013-936X (Linking)
VI  - 46
IP  - 14
DP  - 2012 Jul 17
TI  - Blood concentrations of persistent organic pollutants and prediabetes and 
      diabetes in the general population of Catalonia.
PG  - 7799-810
LID - 10.1021/es300712g [doi]
AB  - The aim was to analyze the effects of body mass index (BMI), low-dose exposure, 
      mixtures of persistent organic pollutants (POPs), and lipid adjustment on the 
      relationship between POP concentrations and diabetes and prediabetes in the 
      general adult population of Catalonia (Spain). Serum concentrations of POPs were 
      measured by gas chromatography with electron-capture detection in 886 
      participants in a health interview survey. The highest concentrations of all POPs 
      analyzed were found in subjects who had diabetes. Levels were also higher in 
      individuals with prediabetes than in subjects without the disorder. In models 
      adjusted by age, sex and BMI, the prevalence of diabetes and prediabetes 
      increased in a dose-dependent manner across quartiles of PCBs 118, 138, 153, and 
      180, and HCB. When models were further adjusted for lipids, the associations were 
      slightly lower and statistically significant, the ORs for the upper quartile 
      ranging from 2.0 to 2.8 (all p-values for linear trend <0.05). Concentrations of 
      p,p'-DDT, p,p'-DDE and beta-HCH were not associated with diabetes or prediabetes. 
      Increasing concentrations of PCBs and HCB were positively associated with 
      diabetes and prediabetes. Only part of the association was due to age and BMI. 
      Findings support the hypothesis that exposure to POPs may be a diabetogenic 
      factor in both obese and nonobese individuals.
FAU - Gasull, Magda
AU  - Gasull M
AD  - Hospital del Mar Research Institute-IMIM, Barcelona, Spain.
FAU - Pumarega, Jose
AU  - Pumarega J
FAU - Tellez-Plaza, Maria
AU  - Tellez-Plaza M
FAU - Castell, Conxa
AU  - Castell C
FAU - Tresserras, Ricard
AU  - Tresserras R
FAU - Lee, Duk Hee
AU  - Lee DH
FAU - Porta, Miquel
AU  - Porta M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120620
PL  - United States
TA  - Environ Sci Technol
JT  - Environmental science & technology
JID - 0213155
RN  - 0 (Environmental Pollutants)
RN  - 0 (Organic Chemicals)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Body Mass Index
MH  - Confidence Intervals
MH  - Diabetes Mellitus/*blood/epidemiology
MH  - Environmental Pollutants/*blood
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Odds Ratio
MH  - Organic Chemicals/*blood
MH  - Polychlorinated Biphenyls/blood
MH  - Prediabetic State/*blood/epidemiology
MH  - Prevalence
MH  - Spain/epidemiology
EDAT- 2012/06/12 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/06/12 06:00
PHST- 2012/06/12 06:00 [entrez]
PHST- 2012/06/12 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - 10.1021/es300712g [doi]
PST - ppublish
SO  - Environ Sci Technol. 2012 Jul 17;46(14):7799-810. doi: 10.1021/es300712g. Epub 
      2012 Jun 20.