PMID- 22682508
OWN - NLM
STAT- MEDLINE
DCOM- 20130109
LR  - 20220318
IS  - 1879-1379 (Electronic)
IS  - 0022-3956 (Linking)
VI  - 46
IP  - 9
DP  - 2012 Sep
TI  - Depression, the Val66Met polymorphism, age, and gender influence the serum BDNF 
      level.
PG  - 1118-25
LID - 10.1016/j.jpsychires.2012.05.003 [doi]
AB  - Brain-derived neurotrophic factor (BDNF) has been suggested as a candidate gene 
      for depression and numerous studies have investigated the possible association 
      between genetic variants within BDNF and depression. Clinical studies have 
      investigated the serum BDNF levels in individuals with depression. However, few 
      studies have combined genetic association studies with serum BDNF measurements. 
      The purpose of the present study was therefore to perform an investigation of 
      BDNF using 162 individuals with depression and 289 healthy individuals. All 
      individuals returned a completed questionnaire and participated in a 
      semi-structured diagnostic interview. The major contribution of the present study 
      is the integration of clinical assessment of cases and control individuals, 
      simultaneous analyses of several genetic variants, serum BDNF measurements, and 
      information on socio-demographic variables, lifestyle, and health indicators in a 
      statistical model. In the present study the serum BDNF levels were increased in 
      the depressive subjects compared to control individuals. Additionally, six SNPs 
      were successfully analyzed, but did not associate with depression. Multiple 
      linear regression models were applied and age, depression, gender, the Val66Met 
      polymorphism, and the interaction between Val66Met and gender were identified as 
      significant determinants of the serum BDNF level. In conclusion, our data 
      demonstrate that other factors than a diagnosis of depression influence the serum 
      BDNF level and the importance of these factors should be emphasized comparing 
      different studies.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Elfving, Betina
AU  - Elfving B
AD  - Centre for Psychiatric Research, Aarhus University Hospital, Risskov, Denmark. 
      betielfv@rm.dk
FAU - Buttenschon, Henriette N
AU  - Buttenschon HN
FAU - Foldager, Leslie
AU  - Foldager L
FAU - Poulsen, Pia H P
AU  - Poulsen PH
FAU - Andersen, Johan H
AU  - Andersen JH
FAU - Grynderup, Matias B
AU  - Grynderup MB
FAU - Hansen, Ase M
AU  - Hansen AM
FAU - Kolstad, Henrik A
AU  - Kolstad HA
FAU - Kaerlev, Linda
AU  - Kaerlev L
FAU - Mikkelsen, Sigurd
AU  - Mikkelsen S
FAU - Thomsen, Jane F
AU  - Thomsen JF
FAU - Borglum, Anders D
AU  - Borglum AD
FAU - Wegener, Gregers
AU  - Wegener G
FAU - Mors, Ole
AU  - Mors O
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120606
PL  - England
TA  - J Psychiatr Res
JT  - Journal of psychiatric research
JID - 0376331
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - AE28F7PNPL (Methionine)
RN  - HG18B9YRS7 (Valine)
SB  - IM
MH  - Adult
MH  - *Aging
MH  - Analysis of Variance
MH  - Brain-Derived Neurotrophic Factor/*blood/*genetics
MH  - *Depression/blood/diagnosis/genetics
MH  - Female
MH  - Genetic Association Studies
MH  - Genotype
MH  - Humans
MH  - Life Style
MH  - Male
MH  - Methionine/*genetics
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - Regression Analysis
MH  - *Sex Characteristics
MH  - Surveys and Questionnaires
MH  - Valine/*genetics
EDAT- 2012/06/12 06:00
MHDA- 2013/01/10 06:00
CRDT- 2012/06/12 06:00
PHST- 2012/02/01 00:00 [received]
PHST- 2012/04/16 00:00 [revised]
PHST- 2012/05/04 00:00 [accepted]
PHST- 2012/06/12 06:00 [entrez]
PHST- 2012/06/12 06:00 [pubmed]
PHST- 2013/01/10 06:00 [medline]
AID - S0022-3956(12)00145-8 [pii]
AID - 10.1016/j.jpsychires.2012.05.003 [doi]
PST - ppublish
SO  - J Psychiatr Res. 2012 Sep;46(9):1118-25. doi: 10.1016/j.jpsychires.2012.05.003. 
      Epub 2012 Jun 6.